# AC 91.11-1: Guide to Drug Hazards in Aviation Medicine - Type: Advisory circular (guidance, not mandatory unless a rule or AD requires it) - Status: Historical - Approved: July 19, 1963 - Last reviewed: August 18, 2020 - Family: AC 91.11-1 - 14 CFR parts: Unknown Part - Pages: 108 - PDF: https://openairdocs.org/files/sha256/10/d0/10d0dde58c7118360ace223dcd13ab643802c03e678d2f3328c53d354d6471e1 - FAA DRS: https://drs.faa.gov/browse/excelExternalWindow/81B99ECC2016242B86256A8C00728EA6.0001 - DRS record last changed: August 18, 2020 - Page: https://openairdocs.org/ac/91.11-1 ## Versions - [AC 91.11-1](https://openairdocs.org/ac/91.11-1) (Historical), approved Jul 19, 1963, 108 pages ## Text Each page's text from the PDF; open the PDF at a page with #page=N. This is OCR from the scanned FAA advisory circular. OCR can misread letters and numbers. ### Page 1 (OCR) AC 91.11 - 1 Cancelled Guide to 91-11-A DRUG **HAZARDS** **AVIATION** **MEDICINE** **FEDERAL AVIATION AGENCY** **AVIATION MEDICAL SERVICE** ### Page 2 (OCR) **GUIDE TO** **DRUG HAZARDS IN** AVIATION MEDICINE Prepared by Windsor C. Cutting, M.D. Stanford University AÃO SEATES OF A 1962 FEDERAL AVIATION AGENCY Aviation Medical Service For sale by the Superintendent of Documents, U.B. Government Printing Office Washington, D.C., 20402 - Price 85 cente ### Page 3 (OCR) Foreword To Each Aviation Medical Examiner: The need for a manual on pharmacology in aviation prompted the Aviation Medical Service of the Federal Aviation Agency to make this handbook available for your guidance. The author, Windsor C. Cutting, M.D., an individual with much passenger flying experience, was for many years Professor of Pharmacology and Therapeutics at Stanford University and now is Professor of Experimental Therapeutics there. Also, he was until 1962 Vice Chairman of the Council on Drugs, American Medical Association. Incorporated are comments submitted by the following consultants who were kind enough to review the manual in preliminary form: Walter Modell, M.D. Associate Professor of Pharmacology and Director of Clinical Pharmacology Cornell University Medical College Herbert S. Kupperman, M.D., Ph.D. Associate Professor of Medicine Department of Therapeutics New York University Medical Center School of Medicine Richard W. Payne, M.D. Associate Professor of Pharmacology and Instructor in Medicine University of Oklahoma School of Medicine H. George Mandel, Ph.D. Professor of Pharmacology. The George Washington University School of Medicine Throughout the manual, Dr. Cutting has confined himself primarily to pharmacological considerations important in evaluating airmen for aviation duties either at the time of routine certification examinations or during treatment for ailments occurring during periods of participation in airmen duties. He has purposely avoided detailed discussions of individual drugs, clinical consideration of pathological states, and policy aspects of the Federal Aviation Agency's certification procedures, except in special instances. ¡ii ### Page 4 (OCR) The manual is, of course, provided only for your guidance, and the individual examiner must consider the details of each case-specific pathology involved, nature of airman's duties, specific drug, exact dosage, individual patient response, and existing regulatory or policy guidelines. After such considerations, the examiner should find himself well prepared to advise patients concerning limitation of airman activities during periods of drug therapy and better able to determine medical qualifications at the time of certification examinations. Necessarily, in any questionable case involving airman certification, the final decision will rest with the Civil Air Surgeon. In conclusion, I wish to express sincere appreciation to Dr. Cutting and the reviewing consultants for their efforts in preparing this manual for your guidance. H. D. ESTEs, M.D., Acting Civil Air Surgeon. iv ### Page 5 (OCR) Preface Probably the best general recommendation for flying personnel and others directly associnted with flight control is abstinence from all drugs. However, some illnesses and symptoms may not preclude flying or ground traffic control work, but may be benefited by appropriate drugs. The question therefore arises as to whether use of the required drugs in such instances may be safe and in fact advantageous. This has led to the preparation of this book for Aviation Medical Examiners. It lists drugs, the toxic effects relevant to aviation that they may produce, and a conservative estimate of their allowable use. The drugs named in this book are arranged so that related drugs are grouped under general therapeutic headings. Individual drug names will be found alphabetically in the index. Mixtures of drugs have not ordinarily been included, but, infrequent synergism aside, the hazards of mixtures may be considered the same as those of their individual components. To simplify the text, salt or ester designations such as hydrochloride or propionate are omitted; their dangers may be assumed to be the same as the free compound. For ease of identification, trade names are given parenthetically after the nonproprietary name. The symptoms listed under the heading &Undesirable effects in aviation" include only those that might be considered important to flying. It is presumed that the examining physicians will ordinarily have access to the name of the drug under question, and will not be faced with a problem of identifying the drug from the symptoms of the patient. Discussion of the latter is beyond the limited scope of this book. Under the heading "Use in aviation personnel" the statement usually reads&Airman duty contraindicated for so many hours or days after use," often with qualifications or exceptions. Customary or usual dosage is assumed. The time limits are intended to be conservative; that is, to indicte the time at which undesirable effects would be presumed to be absent even in sensitive or reactive persons. In only a few instances has it been thought possible to distinguish between the dangers of air duty as opposed to ground duty. It should be stressed that although the likelihood of a drug reaction may disappear after n porticular time, this does not mean that the person is fit for duty. In many instances, it is, of course, inconceivable ### Page 6 (OCR) that a person ill enough to have required a drug would be well enough to work by the time the chance of toxicity from the drug has disappeared. In other instances, the need of a particular drug would of itself indicate a disease state permanently incompatible with flying, ground work, or both. The general medical condition of the patient is always of overriding concern. It should be stressed that the function of the Medical Examiner is to determine the airman's fitness for duty. The first consideration must be to determine whether the disease process of itself, treated or untreated, contraindicates duty; the consideration of the effects of a drug are then secondary in determining final fitness. I am most appreciative of the comments and refinements of Drs. James H. Britton, H. D. Estes, Herbert S. Kupperman, H. George Mandel, Walter Modell, Richard W. Payne, and Homer I. Reighard in their consideration of the text. -WINDSOR C. CUTTING, M.D. vi ### Page 7 (OCR) CONTENTS Page Foreword Preface. 1. ANTIBACTERIAL AND RELATED AGENTS Sulfonamides, systemic and urinary... Sulfonamides, alimentary and others_. Penicillins. Penicillin inhibitor. Erythromycin group. Reserve penicillin substitutes. Tetracyclines- Chloramphenicol Streptomycin group- Streptomycin alternatives. Sulfones. Antituberculosis aynthetica. Nitrofuran derivatives. Urinary antiseptica. 5 Polypeptide antibiotics- 6 2. ANTIFUNGAL AGENTS Nystatin Amphotericin Griseofulvin 3. ANTIPROTOZOAL AGENTS. 8 Quinine 8 Chloroquine group- Chlorguanide group- Primaquine group Emetine. 9 Glaucarubin 9 Oxyquinoline group. Fumagillin_ Metronidazole- Arsenicals_ 10 Bismuth and mercury compounds. Gold compounds.. 10 4. METAL BINDING AGENTS (ANTIDOTES)- Dimercaprol. Ethylenediamine tetraacetic acid salts- Penicillamines. **5. AGENTS IN TROPICAL DISEASES.** Antimonials. Synthetica_ **6. ANTHELMINTICS.** Flatworm agente.. Chlorinated hydrocarbons ### Page 8 (OCR) 6. ANTHELMINTICS--Continued Pape Phenol derivatives 13 Cyanine dyes. 13 Piperazines_ 14 Bephenium 14 Other anthelmintics 14 7. ANTICANCER AGENTS. 15 Alkylating agenta_ 15 Folic acid antagonists. 15 Purine and Pyrimidine Antagonista. 15 Others_. 16 8. TOPICAL AGENTS 17 Insecticides_ 17 Insect repellante. 17 Antiseptics: Phenols, metale, halogens, oxidizing agents, alcohola, dyes 17 Fungicides.. 18 Surface active compounda 18 Sclerosing agents_ 19 Protectives, Emollients, Cosmetics. 19 Sun tan and depigmenting preparations 19 9. CARDIOVASCULAR AGENTS 20 Cardiac glycosides 20 Antiarrhythmics. 20 Agents in heart block 20 Diuretics, osmotic and acidifying.. 21 Diuretics, xanthines. 21 Diuretics, mercurials 21 Diuretics, carbonic anhydrase inhibitora. 22 Diuretice, thiazide and related.. 22 Diuretics, aminouracil derivatives. 22 Diuretice, aldosterone antagonists. 22 Diuretics, catfonic exchange resins 23 Agents inhibiting renal tubules 23 Agents in atherosclerosis 23 Hypotensives, central. 24 Hypotensives, ganglion blockers. 24 Hypotensives, sympatholytics. 25 10. SMOOTH MUSCLE AGENTS 26 Nitrites and nitrates. :6 Xanthines. Papaverine and similar agenta. Ergot alkaloids. 27 Posterior pituitary preparations- 27 11. AGENTS IN BLOOD DISEASES. 28 Iron preparations. 28 Vitamin B,, liver, folic acid preparations 28 Heparin preparations 28 Heparin antagoniste 29 Coumarin and indandione derivatives.. 29 Proteolytic and other enzymes. Vitamin K preparations. **INTARY AGENTS.** regice_ ### Page 9 (OCR) 30. TRANQUILIZERS-Continued Page Antipruritica 70 Reserpine group - 71 Diphenylmethane group- 71 Propanediol-carbamate group- 71 Chlordiazeposide 72 Others_. 72 31. STIMULANTS 73 Nikethamide group- 73 Other medullary stimulants. 73 Reflex stimulants 78 32. PSYCHIC STIMULANTS 74 Xanthine group. 74 Sympathomimetic group- 74 Diphenylmethane group- 74 Amine oxidase inhibitors 74 Dibenzazepine group- 75 33. AGENTS IN ALCOHOLISM. 76 Metabolic inhibitors.. 76 ### Page 10 (OCR) **GUIDE TO DRUG HAZARDS IN** **AVIATION MEDICINE** **1. ANTIBACTERIAL AND RELATED AGENTS** SULFONAMIDES, SYSTEMIC AND URINARY acetylsulfisoxazole (Gantrisin Acetyl) methylsulfanilamidoisoxazole (Gantanoi) sulfacetamide (Sulfamyd) sulfadiazine sulfadimethoxine (Madribon) sulfaethidole (Sul-spansion) sulfamerazine sulfamethazine sulfamethizole (Thiosulfil) sulfamethoxazole (Azo-Gantanol) sulfamethoxypyridazine (Kynex) sulfamidine sulfamonomethoxine sulfamoxole (Nuprin, Sulfuno) sulfaphenazole (Orisul) sulfapyridine sul fasomizole sulfisomidine (Elkosin) sulfisoxazole (Gantrisin) Undesirable effects in aviation: Early: nausea, vomiting, dizziness. Late: dermatitia, rash, agranulocytosis, hepatitis. Use in aulation personnel: Airman duties contraindicated for 24 hours after use. Medical surveillance advisable for 2 weeks, alert to the appearance of late bone marrow and liver damage, which would preclude work. SULFONAMIDES, ALIMENTARY AND OTHERS para-nitrogulfathiazole (Nisulfazole) phthalyleulfathiazole (Sulfathalidine) 1 ### Page 11 (OCR) salicylazosulfapyridine (Salazopyrin) succinylsulfathiazole (Sulfasuxidine) Undesirable effects in aviation: Toxicity minimal but effects like those from systemic sulfonamides may appear occasionally. Use in aviation personnel: Airman duties contraindicated for 1 week after use. A patient needing such agents must be presumed to be too sick for duty. PENICILLINS ampicillin (Penbritin) benzathine penicillin G (Bicillin; Neolin; Permapen) benzathine phenoxymethyl penicillin benzylpenicillin (penicillin G) chlorprocaine penicillin O (Depo-Cer-O-Cillin) diphenicillin (Ancillin) hydrabamine phenoxymethyl penicillin (Compocillin V Hydrabamine) levophenethicillin (L-Maxipen) oxacillin (Prostaphlin) penicillin O (Cer-O-Cillin) phenethicillin (Syncillin) phenoxymethylpenicillin (penicillin V; Pen-Vee Suspension; V-Cillin) potassium phenoxymethyl penicillin (Compocillin VK) procaine penicillin G (Aquacillin; Crysticillin; Duracillin; Eskacillin; Hypercillin) sodium methicillin (Staphcillin) Undesirable effects in aviation: Early and late allergic reactions, including anaphylaxis, urticaria and angioneurotic edema, asthma and dermatitis. Use in aviation personnel: Airman duties contraindicated within 12 hours of use. Duty may be permitted after that time if there is no evidence of late toxicity and examination indicates infection is cured. PENICILLIN INHIBITOR penicillinase (Neutrapen) Undesirable effects in aviation: Fever, local pain, tenderness, allergic reactions. Use in aviation personnel: Airman duties contraindicated for 8 days after use, but in any case patient must be presumed to be too sick for duty. ### Page 12 (OCR) ERYTHROMYCIN GROUP carbomycin (Magnamycin) (withdrawn from market) erythromycin (Ilotycin; Erythrocin) ; free or various esters oleandomycin (Matromycin) spiramycin staphylomycin triacetyloleandomycin (Cyclamycin; TAO) tylosin Undesirable effects in aviation: Relatively free from serious toxic effects. Doses over 0.5 gm. may cause nausea, vomiting and diarrhea. Late: liver damage reported after erythromycin estolate and triacetyloleandomycin. Use in aviation personnel: Airman duties contraindicated for 12 hours after use. Frequent medical examinations indicated for the next 2 weeks. RESERVE PENICILLIN SUBSTITUTES novobiocin (Albamycin; Cathomycin) ristocetin (Spontin) vancomycin (Vancosin) Undesirable effects in aviation: Severe toxic effects, including variously: skin rashes, urticaria, fever, thrombophlebitis, neutropenia, ototoxicity, nephrotoxicity. Use in aviation personnel: Airman duties contraindicated for 1 week after use; additionally, it must be presumed that an illness requiring these drugs precludes duty. TETRACYCLINES chlortetracycline (Aureomycin) demethylchlortetracycline (Declomycin) oxytetracycline (Terramycin) rolitetracycline (Syntetrin) tetracycline (Achromycin; Panmycin; Polycycline; Steclin; Sumycin; Tetrabon; Tetracyn; Tetrex) Undesirable effects in aviation: Larly: nausea, vomiting, diarrhea, light-headedness, photosensitivity (especially to demethylchlortetracycline). Late: glossitis, diarrhea, superinfection with monilia. Use in aviation personnel: Airman duties contraindicated within 12 hours of use, or if any of the listed toxic effects are present, including late or continuing photosensitivity reactions. Frequent medical examinations indicated for the next 2 weeks. ### Page 13 (OCR) CHLORAMPHENICOL chloramphenicol (Chloromycetin) Undesirable effects in aviation: Early: nausea and vomiting, blurring of vision, loss of equilibrium. Late: bone marrow damage, aplastic anemia. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Frequent medical examinations indicated for the next 2 weeks. STREPTOMYCIN GROUP dihydrostreptomycin kanamycin (Kantrex) neomycin (Mycifradin) paromomycin (Humatin) streptomycin Undesirable effects in aviation: Oral administration: nausea, vomiting, cramping and loose stools; later, moniliasis (neomycin, paromomycin). Parenteral administration: severe auditory or vestibular damage (streptomycin, dihydrostreptomycin, neomycin, kanamycin); nephrotoxicity (neomycin, kanamycin); hepatotoxicity (paromomycin); fever, rash, allergic manifestations. Use in aviation personnel: Airman duties contraindicated for 48 hours after use or in the presence of any later signs or symptoms. Frequent medical examinations indicated for the next 2 weeks. Medical condition would ordinarily preclude duty. STREPTOMYCIN ALTERNATIVES cycloserine (Oxamycin) viomycin (Vinactane) Undesirable effects in aviation: Neurotoxicity, convulsions (cycloserine) ; renal and auditory toxicity (viomycin). Use in aviation personnel: Same as for streptomycin. SULFONES diaminodiphenylsulfone (Alvosulfon) glucosulfone (Promin) hydroxyethyl sulfone sodium acetosulfone (Promacetin) sulfoxone (Diasone) thiazolsulfone (Promizole) Undesirable effects in aviation: Excitement, dermatitis, hemolytic anemia. ### Page 14 (OCR) Use in aviation personnel: Work contraindicated for 24 hours after use; no present application except in leprosy, which would ordinarily preclude work. ANTITUBERCULOSIS SYNTHETICS amithiozone (Tibione) benzoylpas (Benzepas) ethionamide (Trecator) isoniazid (Cotinazin; Dinacrin; Ditubin; INH; Isolyn; Isonicop; Laniazid; Nydrazid; Rimifon; Tyvid) para-aminosalicylic acid (Pamisyl; Parapas; Parasal; Pasara) phenyl-p-aminosalicylate (Tebamin) pyrazinamide (Aldinamide) pyruvic acid isonicotinyl hydrazone thiocarbanidin (Thioban) Undesirable effects in aviation: Unpleasant taste and gastric irritation (aminosalicylates) ; drug fever, dermatitia, agranulocytosis (amithiozone); mild euphoria, vertigo, headache, dry mouth (isoniazid, ethionamide) ; hepatic damage, hyperuricemia (pyrazinamide). Use in aviation personnel: Airman duties contraindicated for 48 hours after use; use limited to tuberculosis, which until arrested precludes work. NITROFURAN DERIVATIVES furaltadone (Altafur) (withdrawn from market) furazolidone (Furoxone) nitrofurazone (Furacin) nitrofurantoin (Furadantin) Undesirable effects in aviation: Allergic sensitization (all derivatives) ; leucopenia, hemolytic anemia (nitrofurantoin, furaltadone) ; nausea, dizziness, pruritis, paralysis of lateral rectus of eye, diminished auditory acuity, peripheral neurological disturbances (furaltadone). Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Frequent medical examinations indicated for the next week. URINARY ANTISEPTICS methenamine mandelate (Mandelamine) phenazopyridine (Pyridium) Undesirable effects in aviation: Relatively nontoxic; rare nausea. ### Page 15 (OCR) Use in aviation personnel: Airman duties ordinarily not contraindicated after usual dosage. POLYPEPTIDE ANTIBIOTICS bacitracin (Baciguent) colistin; sod. colistimethate (Coly-Mycin) polymyxin B (Aerosporin) tyrothricin (Bactratycin; Soluthricin) Undesirable effects in aviation: Topical use: relatively nonsensitizing. Systematic use: nephrotoxicity (bacitracin) ; neurotoxicity (polymyxin, colistin). Use in aviation personnel: Airman duties not contraindicated after topical use; prohibited for 24 hours after systematic use, but medical condition would ordinarily preclude duty. Frequent medical examinations indicated for the next 2 weeks. ### Page 16 (OCR) Undesirable effects in aviation: Nausea, vomiting, abdominal cramps, methemoglobinemia, hemolysis. Use in aviation personnel: Airman duties contraindicated for 48 hours after use. Medical condition would ordinarily preclude duty. EMETINE emetine Undesirable effects in aviation: Local irritation, cardiac depression and damage. Use in aviation personnel: Airman duties contraindicated for 1 week after use. Medical condition would ordinarily preclude duty. GLAUCARUBIN glaucarubin (Glarubin) Undesirable effects in aviation: Doses over 200 mg. daily may produce nausea and vomiting. Use in aviation personnel: Work contraindicated for 24 hours after use. Frequent medical examinations indicated during the next week. OXYQUINOLINE GROUP chiniofon (Yatren) diiodohydroxyquin (Diodoquin; Lanodoxin; Moebiquin; Quinadone; Yodoxin) iodochlorhydroxyquin (Enterokin; Enteroquinol; Nioform; Quinambicide; Vioform) Undesirable effects in aviation: Local irritation; rare iodism. Use in aviation personnel: Airman duties ordinarily not contraindicated during topical use; contraindicated for 2 days after systematic use. Disease requiring systematic use ordinarily precludes duty. FUMAGILLIN fumagillin (Fugillin; Fumadil) Undesirable effects in aviation: Cramping, diarrhea, headache, vertigo, dermatitis, neutropenia. Use in aviation personnel: Airman duties contraindicated for 1 week after use. Frequent medical examinations indicated for the next week. ### Page 17 (OCR) METRONIDAZOLE metronidazole (Flagyl) Undesirable effects in aviation: Minor gastrointestinal symptoms and dizziness. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Frequent medical examinations are indicated for the next 2 weeks. ARSENICALS arsphenamine (Salvarsan) carbarsone glycobiarsol (Milibis) neoarsphenamine oxophenarsine (Mapharsen) tryparsamide Undesirable effects in aviation: Local irritation, nitritoid reaction, Herxheimer reaction, jaundice, neuritis (arsphenamines) ; optic atrophy (tryparsamide); largely obsolete. Use in aviation personnel: Airman duties contraindicated during first week of therapy with carbarsone or glycobiarsol, and at all times during use of other drugs listed. BISMUTH AND MERCURY COMPOUNDS bismuth subsalicylate and others mercuric salicylate and others Undesirable effects in aviation: May produce stomatitis, intestinal and renal epithelial damage. Use in aviation personnel: Obsolete; use contraindicated. GOLD COMPOUNDS aurothioglucose (Solganol) aurothioglycainide (Lauron) gold sodium thiomalate (Myochrysine) gold sodium thiosulfate (Auricidine; Aurolin) Undesirable effects in aviation: Metallic taste, stomatitis, pruritis, diarrhea, muscle pain, dermatitis, albuminuria, agranulocytosis. Use in aviation personnel: Airman duties contraindicated for 48 hours after use or in presence of later symptoms; disease ordinarily precludes duty. Frequent medical examinations indicated for the next 2 weeks. ### Page 18 (OCR) **2. ANTIFUNGAL AGENTS** NYSTATIN nystatin (Mycostatin) Undesirable effects in aviation: Relatively nontoxic; occasional nausea, diarrhea, after oral administration, which may persist for several weeks. Use in aviation personnel: Airman duties precludéd by presence of any side effects, but otherwise not contraindicated. AMPHOTERICIN amphotericin B (Fungisone) Undesirable effects in aviation: Fever, chills, anorexia, nausea, vomiting, nephrotoxicity, cardiac depression. Use in avlation personnel: Airman duties contraindicated for 48 hours after use. Frequent medical examinations indicated for the next 2 weeks. Medical condition requiring use would ordinarily be presumed to prevent duty. GRISEOFULVIN griseofulvin (Fulvicin; Grifulvin) Undesirable effects in aviation: Relatively nontoxic; rare headache, insomnia, nausea, rash, fever, joint pains, leucopenia, psychomotor disturbances. Use in aviation personnel: Airman duties contraindicated during first week of use, but not necessarily thereafter during continuation of therapy if toxicity clearly absent. ### Page 19 (OCR) **3. ANTIPROTOZOAL AGENTS** QUININE quinine Undesirable effects in aviation: Deafness, tinnitus, vertigo, nausea, cardiac depression, allergic hypersensitivity. Use in aviation personnel: Airman duties contraindicated for 48 hours after use; may be permitted after that time if examination reveals no vestibular disturbances. However, medical condition would ordinarily preclude duty during therapeutic use. CHLOROQUINE GROUP amodiaquin (Camoquin) chloroquine (Aralen) hydroxychloroquine (Plaquenil) quinacrine (Atabrine) Undesirable effects in aviation: Early: anorexia, nausea, diarrhea, headache, blurred vision, pruritis. Late: ocular palsies, neuropathies, lenticular opacities. Use in aviation personnel: Airman duties not contraindicated during usual suppressive antimalarial doses; contraindicated for 48 hours after therapeutic dosage. Medical examination indicated before return to duty to eliminate presence of early or late toxic effects. Medical condition ordinarily precludes duty during therapeutic use. CHLORGUANIDE GROUP chlorguanide (Guanatol; Paludrine) pyrimethamine (Daraprim) Undesirable effects in aviation: Toxicity relatively slight; nausea, vomiting, diarrhea (chlorguanide); dermatitis, marrow depression, convulsions (high doses of pyrimethamine). Use in aviation personnel: Same as for chloroquine group. PRIMAQUINE GROUP pamaquine (obsolete) pentaquine (obsolete) primaquine ### Page 20 (OCR) **6. ANTHELMINTICS** FLATWORM AGENTS aspidium (male fern) pelletierine quinacrine: see ANTIPROTOZOAL AGENTS Undesirable effects in aviation: Hendache, vertigo, blindness, collapse, convulsions. Use in aulation personnel: Work contraindicated for 48 hours after use. , CHLORINATED HYDROCARBONS carbon tetrachloride tetrachlorethylene Undesirable effects in aviation: Dizziness, staggering, narcosis; later, hepatitis. Use in aulation personnel: Work contraindicated for 48 hours after use. Frequent medical examinations indicated for the next 2 weeks. PHENOL DERIVATIVES hexylresorcinol thymol Undesirable effects in avlation: Local irritation; but severe tox- . icity unlikely. Use in aviation personnel: Airman duties contraindicated for 48 hours after use. CYANINE DYES dithiazanine (Delvex) pyrvinium (Poquil; Povan; Vanquin) Undesirable effecta in aviation: Frequent nnusen, vomiting, and other gastrointestinal symptoms; possible nephrotoxicity. Use in avlation personnel: Airman duties contraindicated for 2 days after use. ### Page 21 (OCR) PIPERAZINES diethylcarbamazine (Hetrazan) piperazine (Antepar; Anthelcole; Oxucide; Pipazan) Undesirable effects in aviation: Infrequent nausea, vomiting, headaches, abdominal cramps, urticaria, neurological disturbances (piperazine); nausea, headache, fever, dermatitis, allergic reactions (diethylcarbamazine). Use in aviation personnel: Airman duties contraindicated for 48 hours (piperazine), and 72 hours (diethylcarbamazine), after use. BEPHENIOM bephenium (Alcopar) Undesirable effects in aviation: Slight nausea, vomiting, soft stools. Use in aviation personnel: Airman duties contraindicated for 48 hours after use. OTHER ANTHELMINTICS methylrosaniline (gentian violet) oil of chenopodium santonin Undesirable effects in aviation: Various mild and severe side effects. Use in aviation personnel: Airman duties contraindicated for 2 days after use; obsolete. ### Page 22 (OCR) **4. METAL BINDING AGENTS (ANTIDOTES)** DIMERCAPROL dimercaprol (BAL) Undesirable effects in aviation: Massive symptoms may follow large therapeutic doses: unrest, weakness, fatigue, paresthesias, lacrimation, perspiration, vomiting, tachycardia. Use in aviation personnel: Airman duties contraindicated for 1 week after use; metal poisoning for which dimercaprol was given would probably preclude work still further. ETHYLENEDIAMINE TETRAACETIC ACID SALTS edathamil calcium-disodium (calcium disodium versenate) edathamil disodium (Endrate disodium) penthamil calcium trisodium Undesirable effects in aviation: Hypocalcemia (edathamil disodium), but all relatively nontoxic. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Disease requiring use of the agents would ordinarily preclude duty. PENICILLAMINES acetylpenicillamine penicillamine Undesirable effects in aviation: Relatively nontoxic. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Medical condition would be presumed to preclude duty. ### Page 23 (OCR) **5. AGENTS IN TROPICAL DISEASES** ANTIMONIALS antimony potassium tartrate (tartar emetic) stilbamine glucoside (Neostam) stibophen (Fuadin) Undesirable effects in aviation: Trivalent forms (tartar emetic, stibophen) may produce coughing, vomiting, pneumonitis, arthralgic, bradycardia, thrombocytopenia. Pentavalent forms may produce vomiting, anaphylactoid reactions, hepatitis. Use in aviation personnel: Airman duties contraindicated for 72 hours after use. Frequent medical examinations indicated for the next 2 weeks. Medical condition would ordinarily preclude duty. SYNTHETICS aminostilbamidine antrycide hydroxystilbamidine lucanthone (Miracil D) metamidium stilbamidine suramin (Bayer 205; Germanin; Naphuride) Undesirable effects in aviation: Various mild and severe adverse effects. Use in aviation personnel: Airman duties contraindicated for 1 week after use, but patients requiring these agents must be considered unfit for duty. ### Page 24 (OCR) **7. ANTICANCER AGENTS** ALKYLATING AGENTS busulfan (Myleran) chlorambucil (Leukeran) cyclophosphamide (Cytoxan) epipropidine (Lponate) mechlorethamine (Mustargen; nitrogen mustard) sarcolysin thiotepa triethylenemelamine (TEM) uracil mustard Undesirable effects in aviation: Certain members (nitrogen mustards) are local vesicants and necrotizing agents; all may produce abdominal pain, diarrhea, nausea, muscular paralysis, convulsions, damage to the bone marrow (early and delayed). Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in the presence of any of the adverse effects. Medical conditions requiring such medications would ordinarily preclude flying. FOLIC ACID ANTAGONISTS aminopterin methotrexate (amethopterin) Undesirable effects in aviation: Ulceration of buccal mucosa, bleeding gums, diarrhen, purpura, ecchymoses. Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in the presence of any adverse effects. Medical condition would ordinarily preclude duty. PURINE AND PYRIMIDINE ANTAGONISTS 5-fluorouracil mercaptopurine (Purinethol) Undesirable effects in aviation: Nausea, vomiting, bone marrow depression with bleeding, thrombopenin, leucopenia. Use in avlation personnel: Airman duties contraindicated for 1 week after use, or in the presence of adverse effects. Medical condition would ordinarily preclude duty. ### Page 25 (OCR) OTHERS azaserine demecolcine (Colcemid) meractinomycin (Actinomycin D) puromycin urethane vinblastine (Velban) Undesirable effects in aviation: Nausea, vomiting, diarrhea and various other symptoms. Use in aviation personnel: Airman duties contraindicated for 1 week after use; also, on medical grounds, patient must be presumed unfit for duty. ### Page 26 (OCR) cetyl pyridinium (Ceepryn) soap sodium lauryl sulfate sodium tetradecyl sulfate (Sotradecol; Tergitol) triclobisonium (Triburon) Undesirable effects in aviation: Relatively nontoxic. Use in aviation personnel: Airman duties not restricted after topical use in conventional dosage. SCLEROSING AGENTS sodium morrhuate sodium psylliate sodium ricinoleate sodium tetracedyl sulfate (Sotradecol) Undesirable effects in aviation: Local irritation and inflammation. Use in aviation personnel: Airman duties contraindicated for 1 week after use; thereafter permitted when examination shows vascular process healed. PROTECTIVES, EMOLLIENTS, COSMETICS Undesirable effects in aviation: None. Use in aviation personnel: Airman duties not contraindicated. SUN TAN AND DEPIGMENTING PREPARATIONS dioxyacetone (Man-Tan) methoxsalen (Meloxine; Methoxa-Dome; Oxsoralen) monobenzone (Benoquin) Undesirable effects in aviation: May produce severe erythema and blistering; liver damage from systemic administration of methoxsalen. Use in aviation personnel: Airman duties contraindicated for 24 hours after use or in presence of signs of toxicity. Frequent medical examinations indicated for the next 2 weeks. ### Page 27 (OCR) **9. CARDIOVASCULAR AGENTS** CARDIAC GLYCOSIDES acetyldigitoxin (Acylanid) deslanoside (Cedilanid D) digilanid digitalis digitoxin digoxin (Lanoxin) gitalin (Gitalgin) ouabain Undesirable effects in aviation: May produce anorexia, nausea, vomiting, diarrhea, visual abnormalities, arrhythmias. Use in aviation personnel: Airman duties contraindicated for 2 weeks after initiation of use. Thereafter, well stabilized digitalization is not of itself a contraindication to duty. However, the medical condition requiring digitalization would almost certainly preclude work. ANTIARRHYTHMICS quinidine procaine amide (Pronestyl) Undesirable effects in aviation: Nausea, vomiting, diarrhea, tinnitus, arrhythmias, sensitivity phenomena, thrombocytopenia from quinidine; hypotension, granulocytopenia from procaine amide. Use in aulation personnel: Airman duties contraindicated for 2 days after cessation of treatment; patient ordinarily considered permanently unfit for work because of underlying disease. AGENTS IN HEART BLOCK ephedrine isoproterenol (Aleudrin; Asdrin; Isopro; Ieuprel) Undesirable effects in aviation: Palpitation, tachycardia, nervousness. Use in aulation personnel; Airman duties contraindicated for 6 hourg after use; however, medical condition (heart block) must be presumed to prohibit duty permanently. ### Page 28 (OCR) DIURETICS, OSMOTIC AND ACIDIFYING ammonium chloride potassium salts sorbitol area Undesirable effecta in aviation: Dehydration, electrolyte disturbances. Use in aviation personnel: Airman duties contraindicated for 24 hours or longer after use, and in any case are permissible only after examination shows effecte of agenta on electrolytes to have ceased. Medical condition ordinarily precludes duty. DIURETICS, XANTHINES aminophylline (Aminocardol; Cardophyllin; Diophyllin; Metaphyllin) theophylline Undesirable effects in aviation: Immediate nausea and vomiting after oral, rectal or intravenous administration; later dehydration, electrolyte disturbances. Use in avlation personnel: Airman duties contraindicated for 24 hours or longer after use, and in any case are permissible only after examination shows effects of agente on electrolytes to have ceased. Medical condition ordinarily precludes duty. DIURETICS, MERCURIALS chlormerodrin (Neohydrin) meralluride (Mercuhydrin) mercaptomerin (Thiomerin) mercumatilin (Cumertilin) mercurophylline (Mercuzanthin) mersalyl sodium and theophylline (Diureal; Merphylline; Salyrgan theophylline) Undesirable effects in aviation: Stomatitis, renal damage, fever, rash; ventricular fibrillation after intravenus use; electrolyte abnormality. Use in aulation personnel: Airman duties contraindicated for 48 hours after use; or 1 week after appearance of any adverse effects, and in any case are permissible only after examination shows effects of agents on electrolytes to have ceased. Medical condition ordinarily precludes duty. ### Page 29 (OCR) DIURETICS, CARBONIC ANHYDRASE INHIBITORS acetazolamide (Diamox) dichlorphenamide (Daranide) ethoxzolamide (Cardrase) methazolamide (Neptazane) Undesirable effects in aviation: Anorexia, fatigue, drowsiness, tingling, leg pains. Use in aviation personnel: Airman duties contraindicated for 48 hours after use of agents for any reason, or for 1 week after appearance of any adverse effects. However, usual indications ordinarily (edema), or absolutely (epilepsy, glaucoma) contraindicate duty. DIURETICS, THIAZIDE AND RELATED bendroflumethinzide (Naturetin) benzthiazide (Di-ademil) chlorthalidone (Hygroton) chlorthiazide (Diuril) flumethiazide (Ademol) hydrochlorothiazide (Esidrix; Hydrodiuril; Oretic) methy clothiazide (Enduron) polythiazide (Renese) trichlormethiazide (Naqua) Undesirable effects in aviation: Minor nausea and vomiting; weakness from potassium deficiency; rare agranulocytosis, thrombocytopenia. Use in avlation personnel: Airman duties contraindicated for 48 hours after use, or for 1 week after appearance of any adverse effects. Medical condition requiring use would ordinarily preclude duty permanently. DIURETICS, AMINOURACIL DERIVATIVES aminometradine (Mictine) amisometradine (Rolicton) Undesirable effects in aviation: Toxicity minimal but nausea, vomiting, diarrhea, dizziness and rash may appear. Use in aviation personnel: Airman duties contraindicated for 24 hours after use (nearly obsolete). DIURETICS, ALDOSTERONE ANTAGONISTS spironolactone (Aldactone) 22 ### Page 30 (OCR) Undesirable effects in aviation: Rare headache, drowsiness, abdominal pain. Use in avlation personnel: Airman duties contraindicated for 24 hours after use. Medical conditions requiring use would ordinarily preclude duty permanently. DIURETICS, CATIONIC EXCHANGE RESINS carbacrylamine resins (Carbo-Resin) Undesirable effects in aviation: May produce nausea from local irritation; constipation from bulk. Use in aviation personnel: Airman duties contraindicated in the presence of any side effects. Howevet, conditions requiring use would ordinarily preclude duty permanently. (Little used). AGENTS INHIBITING RENAL TUBULES (REABSORPTION OF URIC ACID; EXCRETION OF PENICILLIN) probenecid (Benemid) sulfinpyrazone (Anturane) zoxazolamine (Flexin) (withdrawn from market) Undesirable effects in aviation: Nausea, vomiting, anorexia, rashes; activation of peptic ulcer and bone marrow depression (sulfinpyrazone) ; liver damage (zoxazolamine). Use in aviation personnel: Airman duties contraindicated for 48 hours after use. Frequent medical examinations for the next week. AGENTS IN ATHEROSCLEROSIS heparin nicotinic acid; niacin saflower oil (Saff; Saffola; Saffolin) sitosterols (Cytellin) sodium dextrothyroxin (Choloxin) thyrotropic acid (Triopron) triparanol (MER-29) (withdrawn from market) unsaturated fatty acids Undesirable effects in aviation: Minimal adverse effects except for unpleasant immediate flushing from nicotinic acid and undetermined hazards (alopecia, cataracts, accumulation of cholesterol precursor) from triparanol. Use in aviation personnel: Airman duties contraindicated during use of triparanol, for 4 hours after nicotinic acid, 6 hours after heparin; otherwise not contraindicated if adverse effects absent. ### Page 31 (OCR) However, the presence of atherosclerosis requiring treatment ordinarily precludes duty. HYPOTENSIVES, CENTRAL alkavervir (Veriloid) hydralazine (Apresoline) protoveratrines A & B (Veralba) rauwolfia group reserpine (Crystoserpine; Eskaserp; Rau-Sed; Reserpoid; Roxinoid; Serfin; Serpasil; Serpiloid) syrosingopine (Singoserp) Undesirable effects in aviation: Postural hypotension, headache, vomiting, diarrhea. From hydralazine: edema, urticaria, polyneuritis, systemic lupus erythematosus. From rauwolfia, reserpine, syrosingopine: sedation, nightmares, parkinsonism, nasal stuffiness, bleeding from peptic ulcer. Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in presence of any later drug symptoms. Hypertension requiring treatment ordinarily contraindicates duty. However, patients with formerly mild hypertension, who have been completely controlled by the lower conventional doses of drugs for periods of 6 months or longer, and who show no postural hypotension or other adverse effects of drug therapy, may be considered for restricted duty. HYPOTENSIVES, GANGLION BLOCKERS chlorisondamine (Ecolid) hexamethonium (Bistrium; Esomid; Hexameton; Hiohex; Methjum) mecamylamine (Inversine) pempidine (Perolysen) pentolinium (Ansolysen) tetraethylammonium (Etamon) trimethaphan (Arfonad) Undesirable effects in aviation: Postural hypotension, impaired cerebral and renal circulation, dilated pupils, dry mouth, urinary retention, constipation; central stimulation (mecamylamine). Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in presence of any later drug symptoms. Hypertension requiring treatment ordinarily contraindicates duty. However, patients with formerly mild hypertension, who have been completely controlled by the lower conventional 24 ### Page 32 (OCR) doses of drugs for periods of 6 months or longer, and who show no postural hypotension or other adverse effects of drug therapy, may be considered for restricted duty. HYPOTENSIVES, SYMPATHOLYTICS bretylium (Darenthin) guanethidine (Ismelin) methyldopa (Aldomet) Undesirable effects in aviation: Postural hypotension, nasal stuffiness, drooping eyelids, bradycardia, diarrhea, muscular weakness, mental confusion or sedation, facial pain (bretylium). Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in presence of any later drug symptoms. Hypertension requiring treatment ordinarily contraindicates duty. However, patients with formerly mild hypertension, who have been completely controlled by the lower conventional doses of drugs for periods of 6 months or longer, and who show no postural hypotension or other adverse effects of drug therapy, may be considered for restricted duty. ### Page 33 (OCR) **10. SMOOTH MUSCLE AGENTS** NITRITES AND NITRATES amyl nitrite erythrityl tetranitrate (Erythrol tetranitrate) glyceryl trinitrate isorbide dinitrate (Isordil) mannitol hexanitrate (Maxitrate) octyl nitrite (Octrite) pentaerythritol tetranitrate (Angitet; Circulin; Duotrate; Pencard; Pentritol; Peritrate; Rythritol; Vasodilatol) trolnitrate (Metamine) Undesirable effects in aviation: Flushing, throbbing headache, palpitation, fainting. Use in aviation personnel: Airman duties contraindicated for 12 hours after use. It is to be noted that certain indications (angina pectoris) are absolutely incompatible with duty, while others (mild hypertension, completely controlled for 6 months and without adverse drug effects) might not be disqualifying for certain ground duties. XANTHINES aminophylline diphylline oxytriphylline (Choledyl) theophylline methyl glucamine (Glucophylline) theophylline sodium glycinate (Theoglycinate) Undesirable effects in aviation: Gastric irritation after oral use vomiting after intravenous (see also DIURETICS and PSYCHIC STIMULANTS for other uses). Use in aviation personnel: Airman duties contraindicated for 24 hours after use. PAPAVERINE AND SIMILAR AGENTS amotriphene (Myodil) cyclandelate (Cyclospasmol) dioxyline (Paveril) 26 ### Page 34 (OCR) ethyl papaverine (Ethaverine) papaverine Undesirable effects in aviation: Cardiac depreasion possible from papaverine. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. However, underlying medical conditions (angina pectoris or phlebothrombosis) would contraindicate duty. ERGOT ALKALOIDS dihydroergotamine (DHE 45) ergotamine (Gynergan) methyl ergonovine (Methergine) Undesirable effects in aviation: Nausea, vomiting, vascular spasm. Use in avlation personnel: Airman duties contraindicated for 24 hours after use, or if any side effects are present. It should be noted that repeated attacks of migraine are disqualifying for duty. POSTERIOR PITUITARY PREPARATIONS oxytocin (Pitocin; Syntocinon) posterior pituitary vasopressin (Pitressin) Undesirable effects in aviation: Nausea, abdominal cramps cerebral or coronary artery spasm, water intoxication. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. However, most conditions requiring use (labor, intestinal paresis) ordinarily contraindicate duty for a much longer period; completely controlled diabetes insipidus might be judged compatible with certain duties. ### Page 35 (OCR) **11. AGENTS IN BLOOD DISEASES** IRON PREPARATIONS dextriferon (Astrafer) ferric ammonium citrate ferrocholinate (Chel-Iron; Ferrolip) ferrous fumarate (Ferrospan; Fumasorb; Hemorate; Ircon; Toleron) ferrous gluconate (Fergon; Irox; Nionate) ferrous sulfate (Feosol; Ferralyn; Ferro-Theron; Irosul; Sulferrous) iron dextran complex (Imferon) iron oxide, saccharated (Proferrin) polyferose (Tefron) Undesirable effects in aviation: Indigestion from oral adminis. tration; nitritoid reactions, hemochromatosis from intravenous. Use in aulation personnel: Airman duties not contraindicated after oral use; contraindicated for 12 hours after intravenous use. VITAMIN B,,, LIVER, FOLIC ACID PREPARATIONS calcium leucovorin cyanocobalamin (Vitamin B1a) folic acid hydroxocobalamin (alpha-Redisol) liver injection Undesirable effects in aviation: None. Use in ablation personnel: Airman duties not contraindicated by иве. HEPARIN PREPARATIONS heparin potassium, sublingual (Clarin) heparin repository (Depo-Heparin) heparin sodium (Hed-Heparin; Lipo-Hepin; Liquaemin) Undesirable effects in aviation: Nontorio except for danger of bleeding from excessive doses. ### Page 36 (OCR) Use in aviation personnel: Airman duties contraindicated for 24 hours after use. However, medical status ordinarily precludes duty. HEPARIN ANTAGONISTS hesadimethrine (Polybrene) protamine tolonium (Blutene) Undesirable effects in aviation: Protamine may give shock from overdosage. Use in aulation personnel: Airman duties contraindicated for 24 hours after use; however, the medical indication would ordinarily prohibit duty. COUMARIN AND INDANDIONE DERIVATIVES acenocoumarin (Sintrom) anisindone (Miradon) bishydroxycoumarin (Dicumarol) cyclocumarol (Cumpyran) diphenadione (Dipaxin) ethylbiscoumacetate (Tromexan) phenindione (Danilone; Hedulin; Indon) phenprocoumon (Liquamar) warfarin (Coumadin; Panwarfin; Prothromadin) Undesirable effects in aviation: Danger of bleeding; vomiting, diarrhea, urticaria; hepatitis and agranulocytosis (indandiones). Use in aviation personnel: Airman duties contraindicated during first month of therapy; thereafter therapy per se may not be contraindicated if administration well controlled and signs of overdosage absent. However, the most common use, underlying coronary artery disease, contraindicates duty on medical grounds. PROTEOLYTIC AND OTHER ENZYMES chymotrypsin (Chymar; Chymotest; Enzeon) fibrinolysin (human) (Actase; Thrombolysin) pancreatic dornase (Dornavac) streptokinase-streptodornase (Varidase) trypsin (Orenzyme; Parenzyme; Tryptar; Tryptest) Undesirable effects in aviation: Febrile reactions, allergic symptoms after parenteral use. ### Page 37 (OCR) Use in aviation personnel: Airman duties contraindicated for 2 days after parenteral use; for 24 hours after local use. Medical condition would often preclude duty. VITAMIN K PREPARATIONS menadione (Kanone; Kappaxin; Kayklot; Kayquinone; Thyloquinone) menadione sodium bisulfite (Hykinone) phytonadione (Konakion; Mephyton) vitamin K, oxide Undesirable effects in aviation: Relatively nontoxic in adults. Use in avlation personnel: Airman duties not contraindicated by the toxic effects from the agents. ### Page 38 (OCR) **12. ALIMENTARY AGENTS** ANTACIDS aluminum hydroxide gel (Alcid; Alokreen; Amphogel; Creamalin; Flungel; Gelumina; Hydroxal) aluminum phosphate (Phosphaljel) basic aluminum carbonate (Basaljel) calcium carbonate dihydroxyaluminum amino acetate (Alglyn; Alkam; Alminate; Aspogen; Dimothyn; Robalate) gastric mucin magnesium oxide magnesium trisilicate (Chooz; Magmasil; Salicyl; Trimax; Trinesium; Trisomin) polyamine-methylene resin (Exorbin) sodium bicarbonate Undesirable effects in aviation: Minor constipation or diarrhea. At high altitudes, the CO, liberated by sodium bicarbonate may give dangerously increased intragastric pressure. Use in aviation personnel: Airman duties not contraindicated by most of the agents. However, use of sodium bicarbonate should be limited to ground personnel. ANTICHOLINERGICS (see under PARASYMPATHETIC DEPRESSANTS) EMETICS apomorphine syrup of ipecac zinc sulfate Undesirable effects in aviation: Nausea and vomiting. Use in aviation personnel: Airman duties contraindicated within 24 hours of use by the effects of the drug itself. The underlying medical condition would presumably contraindicate duty for a longer period. CHOLERETICS bile acids bile salts (Chobile; Glycotauro; Plebilin) 31 ### Page 39 (OCR) dehydrocholic acid (Decholin; Dehychol; Dilabil; Hykolex; Oxycholin; Procholon) florantyrone (Zanchol) ox bile extract sodium dehydrocholate Undesirable effects in aviation: Adverse effects unlikely. Use in aviation personnel: Airman duties not contraindicated by use. CATHARTICS: LUBRICANTS, SOFTENERS AND BULKY SUBSTANCES calcium-bis-dioctyl sulfosuccinate (Surfak) dioctyl sodium sulfosuccinate (Colace) emulsion of liquid petrolatum (Agarol; Cremagol; Nivea Cream; Petrogalar) liquid petrolatum (Albolene; Nujol; Saxol; Petronol) methylcellulose (Cellothyl) plantago ovata coating (Konsyl) poloxalkol (Polykol) psyllium hydrophilic mucilloid (Metamucil) sodium carboxymethyl cellulose (Almelose; Apergel; Carbethox; Carmethose; Cethylose; Natulose) Undesirable effects in aviation: Leakage of oil from anus; inspissation of fecal mass. Use in aviation personnel: Airman duties not contraindicated by use. CATHARTICS: SALINE, VEGETABLE AND OTHER aloe aromatic fluid extract of cascara bisacodyl (Ducolax) cascara castor oil diacetyldihydroxyphenylisatin (Isacen) magnesia magma (Milk of Magnesia) magnesium citrate magnesium sulfate mild mercurous chloride (Calomel) phenolphthalein rhubarb senna sodium phosphate sodium sulfate 32 ### Page 40 (OCR) 36 tetanus antitoxin scarlet fever immune serum poliomyelitis immune globulin pertussis immune serum immune serum globulin hyperimmunized gamma-globulin gas gangrene antitoxin (various types) diphtheria antitoxin antivenin (various types) IMMUNE SERA vaccine and smallpox vaccine which do not contraindicate duty. hours or longer if reaction persists, except after oral poliovirus Use in aviation personnel: Airman duties contraindicated for 24 lassitude, aching to varying degrees. Undesirable effects in aviation: Local pain, nausea, vomiting, yellow fever vaccine typhoid and paratyphoid vaccine (various forma) tuberculosis vaccine (BCG) smallpox vaccine rabies vaccine poliomyelitis virus vaccine (killed and attenuated) plague vaccine pertussia vaccine (various forms) mumps virus vaccine influenza virus vaccine epidemic typhus vaccine cholera vaccine adenovirus vaccine VACCINES Use in aviation personnel: Work not contraindicated after use. Undesirable effects in aviation: Local pain and soreness. tetanus toxoid (various forms) diphtheria toxoid (various forms) **TOXINS AND TOXOIDS** **14. AGENTS FOR IMMUNOLOGY AND ALLERGY** ### Page 41 (OCR) cular twitching, rare hyperpyresia. The drowsiness can be a particular hazard because it may not be recognized by the patient, and because it may recur after seeming alertness. Use in avlation personnel: Airman duties contraindicated for 24 hours after administration of usual dose; for 12 hours after one-half of the smallest adult dose listed in USP or NND. ANTIMOTION SICKNESS AGENTS cinnarazine (Mitronal) cyclizine (Marezine) meclizine (Bonamine; Bonine) phenglutaramide (Aturban) Undesirable effects in aviation: Similar to those for antihistamines. Use in aviation personnel: Contraindications same as those for antihistamines. ### Page 42 (OCR) Undesirable effects in aviation: Mild and severe hypersensitivity reactions. Use in aviation personnel: Airman duties contraindicated for 24 hours after use, and in presence of any later effects. ALLERGENIC AND DIAGNOSTIC PREPARATIONS allergenic preparations (danders, dusts, plants and many othere) skin test antigens (diphtheria, streptococcus, mumps, tuberculins) Undesirable effects in aviation: Local whealing and urticaria. Use in avlation personnel: Airman duties contraindicated for 6 hours after use or in presence of any later adverse effects. ANTIHISTAMINES antazoline (Antistine) antergan carbinoxamine (Clistin) chlorcyclizine (Perizil) chlorothen (Tagathen) chlorpheniramine (Chlor-Trimeton) chlorphenoxamine (Systiral) clemizole (Allercur) cyproheptadine (Periactin) dimethpyridene (Forhistal) diphenhydramine (Benadryl) diphenylpraline (Diafen) doxylamine (Decapryn) methapheniline (Diatrine) methapyrilene (Histadyl) methdilazine (Tacaryl) phenindiamine (Thephorin) pheniramine (Trimeton) promethazine (Phenergan) proxamine pyrathiazine (Pyrrolazote) pyrilamine maleate (Antamine; Antihist; Diamidide; Neoantergan; Renstamin; Thylogen) pyrrobutamine (Pyronil) thenalidine (Sandostene) thenyldiamine (Thenfadil) thonzylamine (Anahist; Neo-hetramine) tripellenamine (Pyribenzamine) triprolidine (Actidil) Undesirable effects in aviation: Drowsiness (excitement with phenindiamine), dizziness, dry mouth, headaches, nausea, mus- 37 ### Page 43 (OCR) Undesirable effecta in aviation: Allergic reactions and dermatitis; agranulocytosis. Use in aviation personnel: Airman duties contraindicated until the drug effect is stabilized, and without the presence of adverse symptoms; thereafter it may be permissible for certain types of duty. Periodic medical examinations are indicated during the course of therapy. IODIDES sodium iodide strong iodide solution (Lugol's) Undesirable effects in aviation: Iodism, characterized by dermatitis, bronchitis, stomatitis and mental depression. Use in avlation personnel: Airman duties not contraindicated by iodides in usual dosage if no adverse effects are present. ESTROGENS benzestrol (Octofollin) chlorotrianisene (Tace) dienestrol (Restrol) diethylstilbestrol (Stilbestrol) estradiol (Aquagen; Dimenformon; Diogyn; Estraldine; Ovocyclin; Progynon) estriol (Theedol) estrogenic substances, conjugated (Ammestrogen; Cogenat; Conestron; Estrifol; Konogen; Premarin) estrone (Crystogen; Menagen; Menformin; Theelin; Thelestrin) ethinyl estradiol (Diogyn E; Esteed; Estinyl; Eticyclol; Inestra; Novestrol; Orestralyn) hexestrol methallenestril (Vallestril) piperazine estrone sulfate (Sulestrex) Undesirable effects in aviation: Anorexia, nausea, vomiting, headache. Use in aviation personnel: Airman duties contraindicated only if adverse effects are present. PROGESTINS allylestrenol (Gestanon) ethisterone (Lucorteum; Lutocyclol; Lutoral; Ora-Lutin; Pranone; Progestoral; Tyrosinone) haloprogesterone (Prohalone) hydroxyprogesterone (Delantin) 41 ### Page 44 (OCR) medroxyprogesterone (Provera) norethindrone (Norlutin) norethynodrel (component of Enovid) normetandrone (Orgasteron) progesterone (Colprosterone; Lipo-Lutin; Lucocorteum; Lutocyclin; Syngesterone) Undesirable effects in aviation: Minor nausea. Use in aviation personnel: Airman duties contraindicated only if adverse effects are present. NONSTEROID LUTEAL FACTORS relaxin (Cervilaxin) lututrin (Lutrexin) Undesirable effects in aviation: Rare allergic sensitivity. Use in aviation personnel: Work contraindicated only if adverse effects are present. ANDROGENS dromostanolone (Drolban) fluoxymesterone (Halotestin; Ora-Testryl; Ultrandren) methalone methandrostenolone (Dianabol) methylandrostenediol (Androdiol; Methostan; Nabadial; Neostene; Stenediol) methyltestosterone (Dumogran; Masenone; Metandren; Oreton- M; Testra) nandrolone (Durabolin) norethandrolone (Nilevar) oxymetholone (Aldroyd) stanolone (Androlone; Neodrol) stanozolol (Winstrol) testosterone (Androlin; Mertestate; Neo-Hombreol; Oreton-F; Synandrol; Testobase; Testry!) Undesirable effects in aviation: Acne, baldness, testicular inhibition, priapism, hepatic damage (methyltestosterone, norethandrolone), sodium and water retention, hypercalcemia. Use in avlation personnel: Airman duties contraindicated only if adverse effects are present. GONADOTROPINS chorionic gonadotropin (Antuitrin; APL; Chorioginin; Follutein; Pregny!) ### Page 45 (OCR) **15. HORMONES** ADRENAL MINERAL CORTICOIDS desoxycorticosterone (Cortate; Cortenil; Cortiron; DCA; Syncort) Undesirable effects in aviation: Excessive retention of sodium with edema and hypertension; excessive depletion of potassium with muscular weakness. Use in aviation personnel: Airman duties not contraindicated by the drug in the absence of side effects and when clinical condition is stable. However, underlying medical disease is ordinarily a contraindication to duty. ADRENAL GLUCOSTEROIDS betamethasone (Celestone) chlorprednisone cortisone (Cortogen; Cortone) dexamethasone (Decadron) fludrocortisone (Alflorone) fluocinolone (Synalar) fluoxolonate (Oxylone) hydrocortisone (Cortef; Cortifan; Cortril; Heb-Cort; Hycortole; Hydrocortone) methy|prednisolone (Medrol; Wyacort) prednisolone (Cotolone; Delta-Cortef; Hydeltra; Meticortelone; Ulacort) prednisone (Deltasone; Deltra; Listacort; Metasone; Meticorten; Paracort) triamcinolone (Aristocort) Undesirable effects in aviation: Cushing's syndrome with edema, muscle wasting, osteoporosis, potassium loss and hypertension being particularly relevant to aviation. Also, aggravation of peptic ulcer and diabetes, masking of myocardial infarction, non-restraint of infections, mental changes, euphoria and psychotic reactions. Sudden withdrawal may produce prolonged mental depressions. Use in aviation personnel: Airman duties contraindicated for 3 days after systemic use in customary dosage, or in the presence of any side effects. Topical use not a contraindication to duty. ### Page 46 (OCR) Small, (physiologic) replacement, doses do not contraindicate duty, but the underlying medical state (adrenal insufficiency) ordinarily would. ADRENAL CORTICAL HORMONE ANTAGONISTS mepyrapone (Metopirone) Undesirable effects in aviation: Vertigo; precipitation of adrenal insufficiency. Use in aviation personnel: Airman duties contraindicated within 3 days of use. CORTICOTROPIN corticotropin (ACTH; Acthar; Acthotrop; Cortrophin; Solacthyl) Undesirable effects in aviation: Allergic symptoms possible; otherwise effects similar to, but milder than, adrenal glycosteroids. Use in aviation personnel: Airman duties contraindicated for 2 days after use. THYROID PREPARATIONS levothyroxine, sodium (Synthroid) liothyronine, sodium (Cytomel) thyroid thyroxin (see also Agents in Atherosclerosis under CARDIOVASCULAR AGENTS) Undesirable effects in aviation: Signs and symptoms of hyperthyroidism: nervousness, tremor, sleeplessness, weakness, exophthalmos. Use in aviation personnel: Airman duties not contraindicated when used in dosage adequate to control hypothyroidism without producing any significant hyperthyroidism; administration not permitted for the purpose of inducing hyperthyroidism (e.g. in the treatment of obesity). ANTITHYROID SUBSTANCES carbimazole (Neomercazole) iothiouracil (Itrumil) methimazole (Tapazole) methylthiouracil (Methiocil; Muracil) propylthiouracil thiouracil thiourea 40 ### Page 47 (OCR) Undesirable effects in aviation: Adverse effects unlikely. Use in aviation personnel: Airman duties not contraindicated. INSULINS insulin (all forms) Undesirable effects in aviation: Hypoglycemia with sweating, dizziness, impaired judgment, unconsciousness, convulsions; rare allergic hypersensitivity. Use in aviation personnel: Airman duties contraindicated by Federal Aviation Regulation for any patient taking any amount of insulin. However, if exceptions are made in the future for personnel with ground duty of noncritical nature, the following will provide a guide: Work may be permitted when the patient requires only small doses (less than 15 units) and has been under satisfactory medical control, without laboratory or clinical hypoglycemia, for 3 months. INSULIN SUBSTITUTES chlorpropamide (Diabinese) phenformin (DBI) tolbutamide (Orinase) Undesirable effects in aviation: Chlorpropamide and tolbutamide may produce, variously: indigestion, urticaria, nausea, vomiting, flushing after alcohol, cholestatic jaundice, hypoglycemia (chlorpropamide), neurological disturbances (chlorpropamide), thrombocytopenia, agranulocytosis. Phenformin may produce severe gastrointestinal effects, acidosis and ketosis. Use in aviation personnel: Airman duties contraindicated by Federal Aviation Regulation for a patient taking any amount of such drugs. However, if exceptions are made in the future for personnel with ground duty of noncritical nature, the following will provide a guide: Work may be permitted when the patient has been under satisfactory medical control, without laboratory or clinical hypoglycemia, for 3 months. PARATHYROID parathyroid injection (Parathormone) Undesirable effects in aviation: Excessive dosage may produce hypercalcemia; little therapeutic application. Use in aviation personnel: Airman duties contraindicated for 48 hours after use. Underlying medical condition would ordinarily preclude duty. ### Page 48 (OCR) **16. BLOOD, FLUIDS AND ELECTROLYTES** BLOOD AND BLOOD PRODUCTS albumin, normal human serum human albumin normal human plasma plasma protein fraction, human (Plasmanate) whole blood Undesirable effects in aviation: Incompatibility and other immune reactions; serum hepatitis. Use in aviation personnel: Airman duties contraindicated for 8 days after use. Medical reason for use would ordinarily provide further contraindication. PLASMA SUBSTITUTES dextran (Expandex; Gentran) gelatin solution, special intravenous (Plazmoid) polyvinyl pyrrolidone (Periston; PVP) Undesirable effects in aviation: Toxicity negligible, but immunnological type reactions may occur. Use in aviation personnel: Airman duties contraindicated for 3 days after use. Medical reason for use would ordinarily provide further contraindication. INORGANIC SALTS calcium gluconate calcium lactate calcium salts potassium chloride sodium bicarbonate sodium chloride sodium lactate Undesirable effects in aviation: Oral use in customary dosage unlikely to produce troublesome effects. Parenteral use may produce electrolyte disturbances. Use in aviation personnel: Airman duties not contraindicated after usual oral dosages (except, potassium chloride contraindicates for 24 hours). Work contraindicated after parenteral use for 24 hours. Medical indication would ordinarily preclude duty. ### Page 49 (OCR) **18. AGENTS IN NUTRITION** NUTRITIONAL SUPPLEMENTS, CARBOHYDRATE dextrose (glucose) fructose glucourolactone (Glucurone) Undesirable effects in aviation: Unlikely. Use in aviation personnel: Airman duties not contraindicated by use. NUTRITIONAL SUPPLEMENTS, PROTEIN AND AMINO ACID arginine (Argivene) arginine glutamate (Modumate) glutamic acid methionine (Altara; Amurex; Meonine; Metione) potassium and magnesium salts of aspartic acid (Spartase) protein hydrolysates (Am-B; Amigen; Aminonat; Aminosol; Aminovitox; Amiprote; Calorigen; Caminoids; Casein hydrolysate; Lactamin ; Travamin) sodium glutamate (Glutavene; Glutavite) Undesirable effects in aviation: Relatively nontoxic by mouth; allergic symptoms possible after intravenous use. Use in aviation personnel: Airman duties contraindicated for 24 hours after intravenous use. NUTRITIONAL SUPPLEMENTS, FAT cottonseed oil emulsion (Lipomul) homogenized fat preparations Undesirable effects in aviation: Severe immediate "colloid" reactions may occur after parenteral use, with dyspnea, flushing, urticaria, fever and other symptoms. Use in aviation personnel: Airman duties contraindicated for 8 days after parenteral use. Medical indication for use would presumably contraindicate duty. ### Page 50 (OCR) AGENTS IN OBESITY amphetamine (Amitrene; Amphedrine; Benzedrine) dextroamphetamine (Adrizine; Am-Dex; Dadex; Dexedrine) diethylpropion (Tepanil) methamphetamine (Amphedroxyn; Desoxedrine; Desoxyephedrine; Desoxyn; Desyphed; Drinalfa; Methedrine; Methoxyn; Norodin) phenmetrazine (Preludin) phentermine (Ionamin) phenylpropanolamine (Propadrine) (see also SYMPATHETIC STIMULANTS) Undesirable effects in aviation: Nervousness, wakefulness, errors in judgment, psychotic reactions. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. ### Page 51 (OCR) **21. PARASYMPATHETIC STIMULANTS** PARASYMPATHETIC STIMULANTS, DIRECT bethanechol (Urecholine) carbachol (Carbamiotin; Carcholin; Doryl) furtrethonium (Furmethide) methacholine (Mecholyl) pilocarpine Undesirable effects in aviation: Intestinal cramping, sweating, diarrhea, bronchial constriction, pulmonary edema, asthma. bradycardia, cardiac arrest. Use in aviation personnel: Airman duties contraindicated for 24 hours after local or systemic use. **PARASYMPATHETIC STIMULANTS,** ANTICHOLINESTERASE ambenonium (Mytelase) benzpyrinium (Stigmonene) demecarium (Humorsol) echothiophate (Phospholine) isofluorophate (Fluoropryl) neostigmine (Prostigmine) physostigmine (eserine) Undesirable effects in aviation: Same as parasympathetic stimulants direct, plus some element of muscular weakness. Use in aviation personnel: Airman duties contraindicated for 48 hours after local or systemic use. Medical indication would ordinarily contraindicate duty. ### Page 52 (OCR) **20. SYMPATHETIC DEPRESSANTS** VASODILATORS AND HYPOTENSIVES azapetine (Ilidar) dihydroergot alkaloids (Hydergine) phenoxybenzamine (Dibenzyline) phentolamine (Regitine) piperoxan (Benodaine) tolazoline (Benzazoline; Priscoline; Vasimid) (see also Hypotensives, Sympatholytics, under CARDIOVAS- CULAR AGENTS) Undesirable effects in aviation: Mild to severe side effects common, including variously tachycardia, hyperpnea, postural hypotension and mixed autonomic effects. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. ### Page 53 (OCR) drine; Desoxyn; Desyphed; Drinalfa; Methedrine; Methoxyn; Norodin) phenmetrazine (Preludin) (see also Agents in Obesity under NUTRITION) Undesirable effects in aviation: Wakefulness, nervousness, impaired judgment. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. SMOOTH MUSCLE RELAXANTS isoetharine (Dilabron) isoproterenol (Aleudrin; Aludrin; Asdrin; Isopro; Isuprel) isoxuprine (Vasodilan) nylidrin (Arlidin) protochylol (Caytine) Undesirable effects in aviation: Palpitation, tachycardia, tremulousness, insomnia. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. ### Page 54 (OCR) **19. SYMPATHETIC STIMULANTS** VASOCONSTRICTORS cyclopentamine (Clopane) ephedrine epinephrine (Adrenalin; Supranephrin; Vasodrine) hydroxyamphetamine (Paredrine) isometheptene (Octin) levarterenol (Levophed) mephentermine (Wyamine) metaraminol (Aramine) methoxamine (Vasoxyl) methoxyphenamine (Orthoxine) methylamihoheptane (Oenethy!) methylhexaneamine (Forthane) naphazoline (Privine) nordefrin (Cobefrin) phenylephrine (Isophrin; Neosynephrine; Synasal) phenylpropanolamine (Panamine; Propadrine) pheny propylmethylamine (Vonedrine) propylhexedrine (Benzedrex) racephedrine (Vaponephrin) tetrahydrozoline (Tyzine) tuaminoheptane (Tuamine) xylometazoline (Otrivin) Undesirable effects in aviation: Local use as nasal decongestants seldom produces side effects, but naphazoline may induce wakefulnese. Systemic use may produce, variously: local tissue necrosis (levarterenol) ; trembling, pallor, nervousness (epinephrine). Use in aviation personnel: Airman duties not contraindicated by topical use in the nose, but should not be allowed for 6 hours after systemic use (12 hours for preparations of epinephrine in oil). CENTRAL STIMULANTS amphetamine (Amitrene; Amphedrine; Benzedrine) dextroamphetamine (Adrizine; Am-Dex; Dadex; Dexedrine) methamphetamine (Amphedroxyn; Desoxedrine; Desoxyephe- 49 ### Page 55 (OCR) 54 Parkinsonism would ordinarly be expected to preclude duty. Use in aviation personnel: Same as for antispasmodic group. pupils. Undesirable effects in aviation: Sedation, dry mouth, dilated trihexlphenidyl (Artane; Pipanol) tincture of belladonna stramonium scopolamine procyclidine (Kemadrin) orphenadrine (Disipal) ethopropazide (Parsidol) diethazine (Diparcol) cycrimine (Pagitane) caramiphen (Panparnit; Toryn) benztropin (Cogentin) biperidin (Akineton) belladonna AGENTS CENTRAL DEPRESSANTS AND ANTIPARKINSON hours after use. Use in aviation personnel: Airman duties contraindicated for 24 accommodation after local use in eyes. Undesirable effects in aviation: Dilated pupils and paralyzed tropicamide (Mydriacyl) homatropine eucatropine (Euphthalmine) cyclopentolate (Cyclogyl) CYCLOPLEGICS AND MYDRIATICS precludes flying. present. It is to be noted that the presence of peptic ulcer cal condition permits, providing that no adverse effects are first week of use, but then allowable 24 hours after use if medi- Use in aviation personnel: Airman duties contraindicated during ### Page 56 (OCR) 53 of glaucoma. paralyzed accommodation, difficulty in urination, precipitation Undesirable effects in aviation: Dry mouth, dilated pupils and valethamate (Murel) tridihexethyl (Pathilon) tricyclamol (Elorine) tincture of belladonna propantheline (Pro-Banthine) poldine (Nacton) piperidolate (Dactil) pipenzolate (Piptal) penthienate (Monodral) pentapiperide (Quilene) pavatrine oxyphenonium (Antrenyl) oxyphencyclimine (Daricon) octatropine (Valpin) methscopolamine (Pamine) methantheline (Banthine) mepenzolate (Cantil) isopropamide (Darbid) Novatrin; Sethyl) homatropine (Homapin; Homatromide; Malcotran; Mesopin; hexocyclium (Tral) diphemanil (Prantal) diethylaminoethyldiphenylacetate (adiphenine; Trasentine) dicyclomine (Bentyl) dibutoline (Dibuline) benzomethamine (Cotranul) belladonna atropine amprotropine (Syntropan) amolanone (Amethone) aminopentamide (Centrine) ambutonium adiphenine (Trasentine) **ANTISPASMODICS 22, PARASYMPATHETIC DEPRESSANTS** ### Page 57 (OCR) **23. MYONEURAL AGENTS** MUSCLE RELAXANTS, CURARE TYPE benzoquinonium (Mytolon) chondodendron (Intocostrin) curare decamethonium (Syncurine) dimethyltubocurarine (Metubine) gallamine (Flaxedil) succinylcholine (Anectine; Quelicin; Sucostrin; Suxinyl) tubocurarine (Delacurarine; Mecostrin; Tubadil; Tubarine) Undesirable effects in aviation: Paralysis of muscle; rare extreme respiratory depression. Use in aviation personnel: Airman duties contraindicated for 48 hours after use. Medical condition would usually preclude work. MUSCLE STIMULANTS ambenonium (Mytelase) benzpyrinium (Stigmonene) edrophonium (Tensilon) neostigmine (Prostigmine) pyridostigmine (Mestinon) (see also PARASYMPATHETIC STIMULANTS) Undesirable effects in aviation: Overdosage may produce muscular fasciculations, weakness and paralysis. Use in aviation personnel: Airman duties contraindicated for 24 hours after use; work improbable on medical grounds. MUSCLE RELAXANTS, MEPHENESIN TYPE carisoprodol (Soma) mephenesin (Avosyl; Glyotol; Mephedan; Myanesin; Oranixon; Prolax; Sinan; Tolansin; Toloxyn; Tolserol) mephenesin carbamate (Tolseram) methocarbamol (Robaxin) promoxolane (Dimethylane) styramate (Sinaxar) 55 ### Page 58 (OCR) Undesirable effects in aviation: Sleepiness, weakness, vertigo, lassitude; rare hemolysis and hemoglobinuria (mephenesin). Use in aviation personnel: Airman duties contraindicated for 24 hours after use. MUSCLE RELAXANTS, OTHERS chlormezanone (Trancopal) chlorzoxazone (Paraflex) zoxazolamine (Flexin) (no longer marketed) Undesirable effects in aviation: Headache, weakness, drowsiness, rashes, hepatitis, (chlorzoxazone, zoxazolamine) ; sedation (chlormezanone). Use in aviation personnel: Airman duties contraindicated for 24 hours after use. ### Page 59 (OCR) quinine and urea hydrochloride saligenin Undesirable effects in aviation: Allergic sensitization; local irritation. Use in aviation personnel: Airman duties not contraindicated it no side effects are present. However, underlying condition may contraindicate duty. ### Page 60 (OCR) **25. NON-NARCOTIC ANALGESICS** SALICYLATES acety salicylic acid aspirin calcium acety salicylate carbamide (Calurin) choline salicylate (Arthropan) methyl salicylate (oil of wintergreen) salicylamide (Amid-Sal; Liquiprin, Salamide; Salicin; Salrin) salicylic acid sodium salicylate Undesirable effects in aviation: Nausea, tinnitus, deafness, then diarrhea and hallucinations with excessive dosage; local irritation; infrequent allergic manifestations. Use in aviation personnel: Airman duties not contraindicated by usual dosage (less than 1 gm. of aspirin) unless adverse effects are present. ANILINE DERIVATIVES acetaminophen (Amdil; Anelix; Apamide; Tempra; Tylenol) acetanilid acetophenetidin (Phenacetin) Undesirable effects in aviation: Rare sensitivity; prolonged administration may cause cyanosis and anoxemia from sulf- or methemo-globinemia. Use in aviation personnel: Airman duties not contraindicated by usual dosage (less than 0.5 gm. acetanilid) but chronic use should be avoided. PYRAZOLON DERIVATIVES aminopyrine (Pyramidon) antipyrine oxyphenbutazone (Tandearil) phenylbutazone (Butazolidin) sulfinpyrazone (Anturane) - Undesirable effects in aviation: Nausea, anorexia, vertigo, rashes, water retention; may induce bleeding in peptic ulcer; serious danger of agranulocytosis. ### Page 61 (OCR) **29. ANTICONVULSANTS** BARBITURATE GROUP mephobarbital (Mebaral) metharbital (Gemonil) phenobarbital (Luminal) N-phenylbarbital (Pyrictal) primidone (Mysoline) Undesirable effects in aviation: Excessive sedation and impairment of mental and physical activity. Use in aviation personnel: Airman duties contraindicated for 24 hours after use; however, Federal Aviation Regulation prohibits duty in persons with convulsive disorders. HYDANTOINS diphenylhydantoin (Dilantin; Diphentoin; Diphenylan) ethotoin (Peganone) N-methy phenylethyhydantoin (Mesantoin) Undesirable effects in aviation; Minor sedation, hyperplasia of gums, nystagmus, tremor. Use in aviation personnel: Airman duties contraindicated for 2A hours after use; however, Federal Aviation Regulation prohibits duty in persons with convulsive disorders. OXAZOLIDONES paramethadione (Paradione) trimethadione (Tridione) Undesirable effects in avlation: Glare phenomenon, rashes, fever. Use in aviation personnel: Airman duties contraindicated for 3 days after use; however, Federal Aviation Regulation prohibits duty in persons with convulsive disorders. OTHER ANTICONVULSANTS aminoglutethimide (Elipten) ethosuximide (Zarontin) methsuximide (Celontin) phenacemide (Phenurone) phensuximide (Milontin) 68 ### Page 62 (OCR) Undesirable effects in aviation: Sedation, headache, nausea, vertigo, rash; prolonged use has caused fever and psychosis. Use in aviation personnel: Airman duties contraindicated for 24 hours after a single dose; for 1 week after more continued use. ANTIHISTAMINE SEDATIVES promethazine (Phenergan) propiomazine (Largon) Undesirable effects in aviation: Same as short acting barbiturates. Use in aviation personnel: Airman duties contraindicated for 24 hours after a single dose, or 48 hours after chronic use. ### Page 63 (OCR) **28. SEDATIVES AND HYPNOTICS** HALOGENATED HYDROCARBONS chloral hydrate petrichloral (Perichlor) toloxychlorinol Undesirable effects in aviation: Rapid sedation, but rather short lived. Overdosage may give cardiac depression. Use in aviation personnel: Airman duties contraindicated for 12 hours after use. BROMIDES bromides potassium bromide sodium bromide Undesirable effects in aviation: Continued use may cause psychosis and dermatitis. Use in avlation personnel: Airman duties not contraindicated after a single dose, but prohibited for & weaks after steady use for a week or more; obsolete drugs. PARALDEHYDE paraldehyde Undesirable effects in aviation; Relatively safe in usual doses, but breath highly offensive for 24 hours or more. Use in aviation personnel: Airman duties contraindicated for 2 days after use. UREIDES, CARBAMATES, HIGHER ALCOHOLS allylisopropylacetylcarbamide (Sedormid) bromisovalum (Bromural; Isoval; Kartryl) carbromal (Adalin) ectylurea (Nostyn) emylcamate (Nuncital) ethchlorvynol (Placidyl) ethinamate (Valmid) methylparafynol (Dormison) 65 ### Page 64 (OCR) Undesirable effects in aviation: Relatively feeble depressants and little chance of serious side effects (except for thrombocytopenia from allylisopropylacetylcarbamide). Use in aviation personnel: Airman duties contraindicated for 24 hours after use. BARBITURATES, SHORT AND INTERMEDIATE ACTING allylbarbituric acid (Sandoptal) amobarbital (Amytal) aprobarbital (Alurate) butabarbital (Butisol) butallylonal (Pernoston) cyclobarbital (Phanodorn) diallylbarbituric acid (Dial) heptabarbital (Medomin) pentabarbital (Isobarb; Napental; Nembutal; Pembule; Pental) probarbital (Ipral) secobarbital (Barbosec; Evronal; Seconal; Synate) talbutal (Lotusate) vinbarbital (Delvinal) Undesirable effects in aviation: Often initial excitement, then sleepiness, sedation, impairment of mental and physical activity; minor sedation during recovery often not appreciated adequately by patient. Use in aviation personnel: Airman duties contraindicated for 24 hours after use in usual dosage. BARBITURATES, LONG ACTING barbital (Veronal) phenobarbital (Luminal) Undesirable effects in aviation: Sedation, prolonged, and impairment of mental and physical activity. Use in aviation personnel: Airman duties contraindicated for 24 hours after use; however, after a month or more of therapy with usual dosage, certain types of ground work might be permitted for patients in whom the only observable effect was calmness. However, more often the underlying medical condition would preclude duty. GLUTETHIMIDE GROUP glutethimide (Doriden) methyprylon (Nodular) 66 ### Page 65 (OCR) Undesirable effects in aviation: Variously: drowsiness, ataxia, rashes, diarrhea, leucopenia, hepatic damage. Use in aviation personnel: Airman duties contraindicated for 3 days after use, or in presence of side effects; however, Federal Aviation Regulation prohibits duty in persons with convulsive disorders. ..... ### Page 66 (OCR) **30. TRANQUILIZERS** PHENOTHIAZINE GROUP acetophenazine (Tindal) chlorpromazine (Thorazine) chlorprothixine (Taractan) fluphenazine (Prolixin) mepazine (Pacatal) methoxypromazine (Tentone) perphenazine (Trilafon) piperacetazine (Quide) prochlorperazine (Compazine) promazine (Sparine) thiopropazate (Dartal) thioridazine (Mellaril) trifluoperazine (Stelazine) triflupromazine (Vesprin) Undesirable effects in aviation: Autonomic and metabolic: weakness, chilliness, constipation, stuffy nose, blurred vision, dry mouth, hypotension. CNS: drowsiness, parkinsonism, akathisia, dystonia. Organ damage: obstructive hepatitis, marrow depression and agranulocytosis. Use in aviation personnel: Airman duties contraindicated for 24 hours after use of the drug per se; however, patients requiring tranquilizers are ordinarily excluded from duty. ANTIEMETICS pipamazine (Mornidine) thiethylperazine (Torecan) thioperazine (Vontil) trimethobenzamide (Tigan) Undesirable effects in aviation: Similar to phenothiazine group. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. ANTIPRURITICS methdilazine (Tacary!) trimeprazine (Temaril) 70 ### Page 67 (OCR) Undesirable effects in aviation: Similar to phenothiazine group. Use in aviation personnel: Work contraindicated for 24 hours after use. RESERPINE GROUP alseroxylon (Rauwiloid) deserpidine (Harmonyl) rauwolfia (Abten; Koglucoid; Raudixin; Raulon; Rau-Tab; Rautensin ; Vio-Serpine) rescinamine (Moderil) reserpine (Crystoserpine; Eskaserp; Rau-sed; Reserpoid; Roxinoid; Sandril; Serfin; Serpasil Serpiloid; Serpine) tetrabenazine (Nitoman) Undesirable effects in aviation: Autonomic: nasal congestion, salivation, flushing, vomiting, diarrhea, bradycardia. CNS: sedation, nightmares, parkinsonism. Other: induction of bleeding in peptic ulcer. Use in aviation personnel: Airman duties contraindicated for 1 week after use; however, patients requiring tranquilizers are ordinarily excluded from duty. DIPHENYLMETHANE GROUP azacyclonal (Frenquel) benactyzine (Suavitil) captodiamine (Suvren) haloperidol hydroxyzine (Atarax; Vistaril) piperilate (Sycotrol) Undesirable effects in Aviation: Sedation, autonomic side effects. Use in aviation personnel: Airman duties contraindicated for 12 hours after use; however, patients requiring tranquilizers are ordinarily excluded from duty. PROPANEDIOL-CARBAMATE GROUP meprobamate (Equanil; Meprospan; Miltown) oxanamide (Quinctin) phenaglycodol (Ultran) valnoctamide (Axiquel) Undesirable effects in aviation: Tremulousness, muscular relaxation, sleepiness, nausea, depression, allergic reactions, leucopenin, thromocytopenia, intolerance to alcohol, withdrawal symptoms. ### Page 68 (OCR) Use in aviation personnel: Airman duties contraindicated for 24 hours after use; however, patients requiring tranquilizers are ordinarily excluded from duty. CHLORDIAZEPOXIDE chlordiazepoxide (Librium) Undesirable effects in aviation: Drowsiness, vertigo, ataxia (in doses over 50 mg. per day), syncope, itching, dermatitis, impaired thinking, confusion. Use in aviation personnel: Airman duties contraindicated for 24 hours after use; however, patients requiring tranquilizers are ordinarily excluded from duty. OTHERS amphenidone (Dornwall) clemizole (Allercur) mephenoxalone (Trepidone) Undesirable effects in aviation: Variously: sedation, muscular relaxation. Use in aviation personnel: Airman duties contraindicated for 24 hours after use; however, patients requiring tranquilizers are ordinarily excluded from duty. ### Page 69 (OCR) Undesirable effects in aviation: Excitement, nervousness, dry mouth, constipation, impotence, visual disturbances, hypotension, rash, jaundice. Use in aviation personnel: Airman duties contraindicated for 1 week after use. Medicinal need would probably indicate unfitness for duty. DIBENZAZEPINE GROUP amitriptyline (Elavil) imipramine (Tofranil) Undesirable effects in aviation: Excitement or drowsiness, dry mouth, blurred vision, tachycardia, constipation, allergic reactions, hypotension, cholestatic jaundice, agranulocytosis, parkinsonism, tremor. Use in aviation personnel: Work contraindicated for 1 week after use. Medicinal need would probably indicate unfitness for duty. ### Page 70 (OCR) **33. AGENTS IN ALCOHOLISM** METABOLIC INHIBITORS calcium carbide disulfiram (Antabuse) Undesirable effects in aviation: Distressing effects after the ingestion of alcohol: nausea, vomiting, drowsiness, collapse, psychosis. Use in aviation personnel: Airman duties contraindicated for 2 weeks after use; however, alcoholism precludes duty. ### Page 71 (OCR) 78 10 sulfate) _ 37 Antergan. Auricidine (gold sodium thio- 14 Antepar (piperazine). Aureomycin (chlortetracycline) _ 37 Antazoline_ 38 Aturbane (phenglutaramide).. 37 Antamine (pyrilamine maleate).. 53 Atropine_ 76 Antabuse (disulfiram) - 61 Atophan (cinchophen). 24 Ansolysen (pentolinium).. 71 Atarax (hydroxyzine) _ 29 Aniaindone_ Atabrine (quinacrine) - 63 Anileridine_ 28 Astrafer (dextriferon) - 26 nitrate)_. 31 'amino acetate) .. Angitet (pentaerythritol tetra- Aspogen (dihydroxyaluminum 60 Anelix (acetaminophen) _ 60 Aspirin.. 55 Anectine (succinylcholine). 13 Aspidium... 42 Androlone (stanolone)_. 47 magnesium salts.. 42 Androlin (testosterone). Aspartic acid, potassium and 42 diol)... 20 45 Aadrin (isoproterenol)_. 62) Arthrica (ch Androdiol (methylandrostene- Ancillin (diphenicillin) - 60 Arthropan (choline salicylate) _ Analexin (phenyramidol) 54 Artane (trihexlphenidyl).- 37 Anahiat (thonzylamine) .. 10 Arsphenamine_. 66 Amytal (amobarbital)_. 73 Aromatic spirits of ammonia_. 58 Amylsine (naepaine).. 32 Aromatio fluid extract of cascara. 26 Amyl nitrite.. 50 Arlidin (nylidrin) .. Amydricsine_. 39 Aristocort (triamcinolone) - 47 Amurex (methionine) -. 18 Argyrol (silver protein) .. 53 Amprotropine_ 18 Argyn (silver protein). 2 Ampicillin_. 17 Argivene (arginine) _ 31 Arginine glutamate- Amphotericin B.. 47 gel)_. 47 Arginine-- Amphogel (aluminum hydroxide 24 Arfonad (trimethaphan). 48, 49, 74 Amphetamine.. 49 72 Aramine (meteraminol)_. Amphenidone_. 48, 49 | Aralen (chloroquine) _ mine)_.. 41 Aquagen (estradiol). Amphedroxyn (methampheta- 2 G)_. Amphedrine (amphetamine) - 48, 49, 74- 26 Aquacillin (procaine penicillin Amotripbene_. 66 53 Aprobarbital_ Amolanone_. 24 8 Apresoline (hydralazine). Amodiaquin. 31, 62 66 Apomorphine ... Amobarbital. 42 APL (chorionic gonadotropin). 21, 64 Ammonium chloride.. 32 cellulose)_. 73 Ammonium carbonate. Apergel (sodium carboxymethyl Ammoniated mercury_. 60 Apamide (acetaminophen). 41 stance)_- 23, 60 Anturane (sulfpyrazone) - Ammestrogen (estrogenic sub- 42 tropin).. 75 Amitriptyline_. Antuitrin (chorionie gonado- 48, 49, 74 Amitrene (amphetamine). 12 Antrycide_ 5 Amithiozone_. 53 Antrenyl (oxyphenonium) - 22 Amisometradine.. 36 Antivenin_ 47 Amiprote (protein hydrolysate).. 37 Antistine (antazoline). 73 Amiphenazole_ 60 Antipyrine_ 47 sate) -- 12 Antimony potassium tartrate. Aminovitox (protein hydroly- 37 Antihist (pyrilamine maleate). 12 Aminostilbamidine. Antigens, see Skin test antigens. 47 Aminosol (protein hydrolysate).. 14 Anthelcole (piperazine). 60 Aminopyrine_. Page Page ### Page 72 (OCR) 77 15 81 Aminopterin.. ino scetate).. 21, 26 Aminophylline. Alglyn (dihydroxyaluminum am- 58 Aminopentamide. 39 Alforone (fludrocortisone)_. 47 Aminonat (proteln hydrolysate) _ 20, 50 Aleudrin (isoproterenol).. 22 Aminometradine. 42 Aldroyd (oxymetholone) _ 68 Aminoglutethimide_ 25 Aldomet (methyldopa).. 21 Aminocardol (eminophylline) . Aldinamide (pyrasinamide) _ 47 Amigen (protein hydrolysate)_. 22 Aldactone (spironolactone) .. 60 Amid-Sal (salicylamide)_. 14 Alcopar (bephenium) .. 63 Amidone (methadone) - 31 Alcid (aluminum hydroxide gel)... Amethopterin, see Methotrexate. 44. Albumin, normal human serum.. 53 Amethone (amolanone). 32 Albolene (liquid petrolatum)-. 60 Amdil (acetaminophen) _ Albamycin (novobiocin).. 49, 74 54 Akineton (biperldin).. 48, Am-Dex (dextroamphetamine) -- 32 Agarol (liquid petrolatum emulafon) 53 Ambutonium. 6 Aerosporin (polymyxin B)... 52, 55 Ambenonium - 49, 74 47 Am-B (protein hydrolyaate) 48, Adrizine (dextroamphetamine) .. 58 Alypin (amydricaine) 49 Adrenalin (epinephrine).. fone) _ 53 Adiphenine-. Alvosulfon (diaminodiphenyleul- 36 Adenovirus vaccine.. 66 Alurate (aprobarbital) 22 Ademol (flumethiazide) _ 31 Aluminum phosphate. 65 Adalin (carbromal) _. 31 Aluminum hydroxide gel. 20 Acylanid (acetyldigitoxin).. 50 Aludrin (isoproterenol). 16! cin) _--- 47 Altara (methionine) -. Actinomycin D (meractinomy- Altafur (furaltadone). 37 Actidil (triprolidine).. 71 Alseroxylon_. 40 Acthotrop (corticotropin).. 46 Alpha tocopherol. 40 Acthar (corticotropin) _. 28 Alpha-Redical (hydroxocobalamin) 40 ACTH (corticotropin). 63 Alphaprodine. Actase (fbrinolyain) .. 31 gel) __. 17 Acriflavin_. Alokreen (aluminum hydroxide Achromycin (tetracycline).. 32 "Aloe_ Acetylsulfsoxazole_. 31 amino acetate) _- 60 Acetylealicylic aold. Alminate (dihydroxyaluminum 11 AcetyIpencillamine. 32 cellulose).-- 20: Acetyldigitoxin_. Almelose (sodium carboxmethyl 35 Acetotrizoate_.. 65 Allylisopropylacetylcarbamide. _ 60 Acetophetidin.. 41 Allylestrenol__.. 70 Acetophenazine. 66 Allybarbituric acid. - 22 Acetazolamide. 37 Allergenio preparations- 60 Acetanilid. _ Allecur (clemizole)... 60 Acetaminophen_ 24 Alkavervir_.. 29 Acenocoumarin.. 31 ino acetate)... 71 Abten (rauwolfa) .. Alkam (dihydroxyaluminum am- Page Page INDEX ### Page 73 (OCR) Page Page Aurolin (gold sodium thiosul- Benzoquinonium 55 fate)_. 10 Benzoylpaa_ Aurothioglucose. 10 Benzpyrinium 62, 55 Aurothioglycainide 10 Bengthiazide. 22 Avertin (tribromethanol) 57 Benztropin 54 Avoay. (mephenesin)- 55 Benzyl alcohol. 58 Axiquel (valnoctamide) 71 Benzyl benzoate 17 Azacyclonal. 71 Benzylpenicillin, see Penicillin Azapetine - 51 Azaserine_. 16 Bephenium 14 Azo-Gantanol (sulfamethoxa- Betamethasone. 39 zole) - 1 Betazole. 34 Azuresin 34 Bethanechol. 52 Bicillin (benzathine penicillin B G)_ Bile acids. 31 Baciguent (bacitracidi) Bile salts. 31 Bacitracin_. 6 Biperidin 54 Bactratycin (tyrothricin). 6 Bisacodyl 32 BAL (dimercaprol) 11 Bishydroxy coumarin 29 Bathine (methantheline) - 53 Bismuth subcarbonate. 33 Barbital 66 Bismuth subaalicylate 10 Barbosec (secobarbital) 66 Bismuth tribromphenate 17 Basaljel (basie aluminum carbon- Bistrium (hexamethonium) 24 ste) - 31 Blutene (tolonium) - 29 Basio aluminum carbonate 31 Bonamine (meclizine). 38 Bayer 205 (suramin)_. 12 Bonine (meclizine). 38 BCG (tuberculosis vaccine) 36 Boric acid.. 17 Belladonna. 53, 54 Bretylium 25 Bernegride.. 73 Brevital (methohexital) - 57 Benactyzine 71 Bromisovalum_ 65 Benadryl (diphenhydramine) 87 Bromides 65 Bendroflumethiazide_ 22 Bromthalein (sulfbromphtha- Benemid (probenecid).. 23 lein) - 34 Benodaine (piperoxan) - 51 Bromural (bromisovalum) - 65 Benoquin (monobenzone) 19 Bunamiodyl. 35 Benoxinate 58 Busulfan 15 Bentyl (dicyclomine) - 53 Butabarbital 66 Benzalkonium Butacaine 58 Benzathine penicillin G- Butallylonal. 86 Benzathine phenoxymethyl pen- Butapyronoxyl 17 icillin_ 2 Butazolidin (phenylbutazone) - 60 Benzazoline (tolazoline). 51 Butesin (butylaminobenzoate) 58 Benzedrex (propylhexedrine) - 49 Butethamine_ 58 Benzedrine (amphetamine) - 48, 49, 74 Butisol (butabarbital). 66 Benzene hexachloride- 17 Butyn (butacaine)_ 58 Benzepas (benzoylpas) - 5 Butylaminobenzoate. 58 Benzestrol. 41 Benzethonium. 18 C Benzocaine (ethylaminobenzoate) . 58 Caffeine 74 Benzoic acid. 18, 34 Calciferol 45 Benzomethamine. 53 Calcium acetylsalicylate carba- Benzonatate 64 mide 60 79 ### Page 74 (OCR) Page Page Calcium-bis-dioctyl sulfosueci- Ceepryn (oetyl pyridinium) 19 nate. 32 Celestone (betamethasone) - 39 Calcium carbide. 78 Cellothyl (methyloellulose) 32 Calcium carbonate. 31 Celontin (methsuximide) - 68 Calcium disodium versenate, see Centrine (aminopentamide). 53 Edathamil calcium disodium. Cer-O-Cillin (penicillin 0) - 2 Calcium gluconate. 44 Cervilaxin (relaxin) 42 Calcium lactate_ 44 Cethylose (sodium carboxymeth- Calcium leucovorin 28 yl cellulose) 32 Calcium salta. 44 Cetyl pyridinium 19 Calomel (mild mercurous chlo- Charcoal. 33 ride)_. 32 Chel-Iron (ferrocholinate) - 28 Calorigen (protein hydrolybate) - 47 Chiniofon Calurin (calcium acetylsalicylate Chloral hydrate 65 carbamide) - 60 Chlorambucil.. 15 Caminoids (protein hydrolyaate). 47 Chloramphenicol 4 Camoquin (amodiaquin) - 8 Chlorcyclizine 37 Cantil (mepenzolate) - 53 Chlordiazepoxide. 72 Caprylic compound. 18 Chlorgrafn (iodipamide) - 85 Caprylic salta 18 Chlorguanide. 8 Captodiamine_. 71 Chloriodized oil 35 Caramiphen. 54 | Chlorisondamine. 24 Carbachol 52 Chlormerodrin 21 Carbacrylamine resina. 23 Chlormezanone 56 Carbamiotin (carbachol) - 52 Chloroform. 57 Carbarsone. 10 Chloromycetin (ohlorampheni Carbetapentane. col). 4 Carbethox (sodium carboxy- Chlorophenothane. 17 methyl cellulose) - 32 Chloroquine. 8 Carbimazole_ 40 Chlorothen 37 Carbinoxamine. 37 Chlorotrianisene_ 41 Carbocaine (mepivacaine) 58 Chlorphendianol 64 Carbomycin - Chlorpheniramine. 87 Carbon dioxide- 57 Chlorphenoxamine. 37 Carbo-Resin (carbacrylamine res- Chlorprednisone. 39 ins) - 23 Chlorprocaine. 58 Carbon tetrachloride. 13 Chlorprocaine penicillin O. 2 Carbromal_ 65 Chlorpromazine_ Carcholin (carbachol)- 52 Chlorpropamide Cardiazol (pentylenetetrazol) - 78 | Chlorprothixine. Cardophyllin (aminophylline)- 21 Chlortetracycline Cardrase (ethoxzolamide) - 22 Chlorthalidone. Carisoprodol_ 5Б Chlorthiazide. Carmethose (sodium carboxy. Chlor-Trimeton (chlorpheniramethyl cellulose) .. 32 mine) - Carotene in oil 45 Chlorzoxazone- Cagcara _ 32 Chobile (bile salta) - Casein hydrolyaate (protein hy- Choledyl (oxytriphylline) drolysate) 47 Cholera vaccine. Castor oil_. 32 Choline Cathomycin (novobiocin) 3 Choline salicylate. Catron (pheniprazine) - 74 Choloxin (sodium dextrothy- Caytine (protochylol).. 50 roxin) - 23 Cedilanid D (desianoside) 20 Chondodendron 55 80 ### Page 75 (OCR) 82 5 37 | Dinacrin (isoniazid) - Diamidide (pyrilamine maleate)_ 31 amino acetate) _. 66 Diallylbarbituric acid... Dimothyn (dihydroxyaluminum- 66 Dial (diallyibarbituric acid). 63 Dimorlin (dextromoramide)... 34 Diagnex blue (azuresin)... õ5 Dimethyltubocurarine. 34 resin) _.- 17 Dimethyltolumide_ Diagnex (quinine carbacrylic 17 Dimethylphthalate_ 37 Diafen (diphenylpraline).. 55 Dimethylane (promoxolane) _ 22 Di-ademil (benzthiazide)_. 37 Dimethpyridene_ Diacetyldihydroxphenylisatin. 64 Dimethoxanate_ - 43 Diabinese (chlorpropamide).. 58 Dimethisoquin_. 27 DHE-45 (dihydroergotamin).. 11 Dimercaprol_. Dextrose, see Glucose. 41 Dimenformon (estradiol)_ 63 Dextropropoxyphene_. 62 Dilaudid (dihydromorphinone). 63 Dextromoramide.. 68 Dilantin (diphenylhydantoin). 62 Dextromethorphan. 50 Dilabron (isoetharine) - 48, 49, 74; Dextroamphetamine. 32 Dilabil (dehydrocholic acid) - 28 Dextriferon_. 9 Diiodohydroxyquin 44 Dextran. 31 tate.. 49, 74 Dihydroxyaluminum amino ace- 48, Dexedrine (dextroamphetamine). 45 Dihydrotachysterol.. 39 Dexamethasone_ 4 Dihydrostreptomycin. 64 Detigon (chlorphendianol) - 62 Dihydromorphinone. 48, 50 Desyphed (methamphetamine). 62 Dihydrohydroxycodeinone- Desoxyn (methamphetamine) _ 48, 50, 74 27 Dihydroergotamine. 48, 49 mine).. 51 Dihydroergot alkaloids. Desoxyephedrine (methampheta- 62 Dihydrocodeinone_. 39 Desoxycorticosterone. 20 Digoxin_. Desoxedrine (methamphetamine) 48, 49 20 Digitoxin.. 20 Deslanoside.. 20 Digitalls_. 71 Deserpidine.. 20 Digilanid.. 28 tory)_. 41 DiethyIstilbestro!. Depo-Heparin (heparin reposi- 48 2 Diethylpropion.. penicillin O)_ 14 Diethylcarbamazine. Depo-Cer-O-Cillin (chlorprocaine tate, see Adiphenine. Demethylchlortetracycline. Diethylaminoethyldiphenylace- 63 Demerol (meperidine).. 54 Diethazine. 16, 60 Demecolcine. 41 Dienestrol. 52 Demecarium_ 62 Didrate (drocode). 66 Delvinal (vinbarbital). 53 Dicyclomine_ 13 Delvex (dithiazanine)_. Dicumarol (bishydroxycoumarin) 39 Deltra (prednisone)_. 62 Dicodid (dihydrocodeinone). 39 Deltasone (prednisone)_ 22 Dichlorphenamide_ 39 Delta-Cortef (prednisolone). 53 Dibutoline_ 41 Delantin (hydroxyprogesterone) - 53 Dibuline (dibutoline). 82 Delacurarine (tubocurarine)_. 58 Dibucaine. 32 Dehydrocholic acid.. 51 Dibenzyline (phenoxybenzamine) 32 Dehychol (dehydrocholic acid). 35 Diatrizoate_. cycline) - - 37 Diatrine (methapheniline). Declomycin (demethylchlortetra- Diasone (sulfoxone) - 32 Decholin (dehydrocholic acid). 42 Dianabol (methandrostenolone) - 37 Decapryn-. 63 Diampromide_. 55 Decamethonium. 22 Diamox (acetazolamide). 39 Decadron (dexamethasone). 4 Diaminodipheny lsulfone- 74 Deanol._ Page Page ### Page 76 (OCR) 81 74 Deaner (deanol).. 39 17 DDT (chlorophenothane) - 5 39 DCA (desoxycorticosterone) - 40 43 DBI (phenformin).. 39 63 Darvon (dextropropoxyphene).. 39 70 Dartal (thiopropazate)_- 39 53 Daricon (oxyphencyclimine) - 39 Cortisone_.. 25 Darenthin (bretylium) _ 39 53 Darbid (isopropamide) .. 39 Daraprim (pyrimethamine). 10 Corticotropin. - 22 Daranide (dichlorphenamide) 39 73 Daptazole (amiphenazole).- 39 29 Danilone (phenindione) _ 39 --48, 49, 74 Dadex (dextroamphetamine). 73 53 Dactil (piperidolate) _- 41 D penfcillin)_. 15 Cytoxan (cyclophosphamide). 40 Cytomel (liothyronine, sodium) - 23 Cytellin (sitosterols) _.. 70 37 Cyproheptadine- 6 54 Cycrimine- 12 26 Cyclospasmol (cyclandelate) _ 6 Colistin_. 4 Cycloserine_. 61 Colchicine_ 57 Cyclopropane_ 16, 61 15 Cyclophosphamide. 32 cinate)_.. 54 Cyclopentolate._ suc- 48 Cyclopentamine. 54 58 Cyclomethycaine. 41 se) __ 54 Cyclogyl (cyclopentolate) . 74 Coffee__ 29 Cyclocumarol_ 62 66 Cyclobarbital_ 45 Cod liver oil_. 37 Cyclizine_ 62 Codeine_. 26 Cyclandelate_. 58 Cocaine_. cin) _ 49 Cyclamycin (triacetyloleandomy- 64 58 Cyclaine (hexylcaine)_ 48 28 Cyanocobalamin. 37 55 Curare_. 37, 72 Clemizole_. 29 Cumpyran (cyclocumarol). 33 Claysorb_. 21 Cumertilin (mercumatilin). 28 lingual) _ 24, 71 Crystoserpine (reserpine).- sub- 41 Crystogen (estrone) - 26 nitrate) __ 2 Crysticillin (procaine penicillin G). etre 17 Crotamiton_. 37 Cinnarazine_. 17 Cresol_ 61 Cinchophen_. 32 emulsion) 29 Cremagol (liquid petrolatum 29 31 gel)_ 29 Creamalin (aluminum hydroxide 42 tropin). 29 Coumadin (warfarin) . do_ 47 Cottonseed oil emulsion. 42 53 Cotranul (benzomethamine) 31 te)._ Page Page ### Page 77 (OCR) Page Page Dioctyl sodium sulfosuccinate 32 Durabolin (nandrolone) 42 Diodoquin (diiodohydroxyquin) 9 Duracillin (procaine penicillin G) 2 Diodrast (iodopyracet)- 35 Dyclone (dycyclonine) 58 Diogyn (estradiol)- 41 Dycyclonine 58 Diogyn E (ethinyl estradiol) 41 Dionin (ethyl morphine) - 62 E Dionosil (propyliodone) - 35 Echothiophate 52 Diophyllin (aminophylline). 21 Ecolid (chlorisondamine).. 24 Diothane (diperodon) - 58 Ectylurea 65 Dioxyacetone 19 Edathamil calcium-disodium. 11 Dioxyline_ 26 Edathamil disodium. 11 Diparcol (diethazine)- 54 Edrophonium 55 Dipaxin (diphenadione). 29 Elavil (amitriptyline). 75 Diperodon_ 58 Elipten (aminoglutethimide) 68 Diphemanil 53 Elixir terpin hydrate with codeine Diphenadione 29 and similar mixtures. 62 Diphenhydramine. 37 Elkosin (sulfisomidine) - 1 Diphencillin.. 2 Elorine (tricyolamol) 53 Diphenoxylate 63 Emetine. Diphentoin (diphenylhydantoin) 68 Emivan (ethaminvan) . 73 Diphenylan (diphenylhydantoin) 68 Emylcamate 65 Diphenylhydantoin 68 Endrate disodium (edathamil DiphenyIpraline. 37 disodium) - 11 Diphtheria antitoxin 36 Enduron (methylclothiazide). 22 Diphtheria toxoid 36 Enovid (norethynodrel) - 42 Diphylline. 26 Enterokin (iodochlorhydroxy. Diprotrizoate 35 quin) 9, 17 Dieipal (orphenadrine) - 54 Enteroquinol (iodochlorhydroxy- Disulfiram. 76 quin) _ 9, 17 Dithiazanine. 13 Enzactin (triacetin)- 18 Ditubin (İsoniazid). Enzeon (chymotrypsin) - 29 Diuril (chlorthiazide). 22 Ephedrine 20, 49 Diursal (mersalyl sodium and Epinephrine 49 theophylline) 21 Epipropidine. 15 Dolophine (methadone) 63 Eponate (epipropidine) _. 15 Doriden (glutethimide) 66 Equanil (meprobamate)- 71 Dormison (methylparafynol). 65 Ergotamine 27 Dornavac (pancreatic dornase). 29 Erythrityl tetranitrate. 26 Dornwall (amphenidone) 72 Erthyrocin (erythromycin) - 3 Dorsacaine (benoxinate) 58 Erythrol tetranitrate (erythrityl Doryl (carbachol) - 52 tetranitrate) 26 Dover's powder (powder of ipecac Erythromycin_ 3 and opium).. 62 Eserine, see Physostigmine. Doxylamine. 37 Esidrix (hydrochlorothiazide) 22 Dried yeast. 45 Eskacillin (procaine penicillin Drinalfa (methamphetamine). 48, 50 G) 2 Drocode__ 62 Eskaserp (reserpine) - 24, 71 Drolban (dromostanolone) - 42 Esomid (hexamethonium) - 24 Dromostanolone.. 42 Esteed (ethinyl estradiol).. 41 Ducolax (bisacodyl) - . 32 Estinyl (ethinyl estradiol) - Dumogran (methyltestosterone) 42 Estradiol. 41 Duotrate (pentaerythritol tetra- Estraldine (estradiol) - 41 nitrate) 26 | Estrifol (estrogenic substance) - 83 ### Page 78 (OCR) Page Page Estriol- 41 Fibrinolysin, human 29 Estrogens- 41 Fish liver oils. 45 Estrone - 41 5-Fluorouracil - 15 Etamon (tetraethylammonium) - 24 Flagyl (metronidazole) - 10 Ethamivan 73 Flaxedil (gallamine). 55 Ethaverine (ethyl papaverine) - 27 Flexin (zoxazolamine) - 23, 56 Ethchlorvynol_ 65 Florantyrone. 32 Ether 57 Fluage) (aluminum hydroxide Ethinamate_. 65 gel).- 31 Ethinyl estradiol. 41 Fludrocortisone_. 39 Ethionamide. 5 Flumethiazide.. 22 Ethisterone 41 Fluocinolone. 39 Ethnine. 62 Fluormar (trifluoroethylvinyl Ethoheptazine 63 ether) - 57 Ethohexadiol 17 Fluoropryl (isofluorophate)- 52 Ethopropazide. 54 Fluothane (halothane) - 57 Ethosuximide. 68 | Fluoxolonate_ 39 Ethotoin 68 Fluoxymesterone- 42 Ethoxzolamide 22 | Fluphenazine- 70 Ethyl alcohol. 17 Folic acid.. 28 Ethylaminobenzoate 58 Follutein (chorionic gonadotro- Ethylbiscoumacetate 29 pin) 42 Ethyl cartrizoate. 35 Forhistal (dimethpyridene) - 37 Ethyl chloride. 57, 58 Forthane (methylhexaneamine) - 49 Ethylene 57 Frenquel (azacyclonal)- 71 Ethyl morphine- 62 Fructose. 47 Ethyl papaverine 27 Fuadin (stibophen) - 12 Eticyclol (ethinyl estradiol) 41 Fugillin (fumagillin)- Etryptamine 74 Fulvicin (griseofulvin)- 7 Eucatropine. 54 Fumadil (fumagillin) - 9 Eugenol. 58 Fumagillin. 9 Euphthalmine (eucatropine) 54 Fumasorb (ferrous fumarate) - 28 Eurax (crotamiton) _ 17 Fungisone (amphotercin B)- 7 Evans blue- 34 Furacin (nitrofurazone). 5 Evipal (hexobarbital) - 57 Furadantin (nitrofurantoin)- 5 Evipan (hexobarbital) 67 Furaltadone. 5 Evronal (secobarbital) 66 Furazolidone- Exorbin (polyamine-methylene Furmethide (furtrethonium) - 52 resin) - 31 Furoxone (furazolidone). 5 Expandex (dextran) 44 Furtrethonium. 52 F G Galactose_ 34 Feosol (ferrous sulfate) -. 28 Gallamine. 55 Fergon (ferrous gluconate) - 28 Gamophen (hexachlorophene) - 17 Ferralyn (ferrous sulfate) - 28 Gantanol (methyleulfanilamidoi- Ferric ammonium citrate. 28 Boxazole) - 1 Ferrocholinate- 28 Gantrisin (sulfisoxazole) .. Ferrolip (ferrocholinate) 28 Gantrisin Acetyl (acetylsulfisoxa- Ferrospan (ferrous fumarate) _ 28 zole) -. 1 Ferro-Theron (ferrous sulfate). 28 Gas gangrene antitoxin 36 Ferrous fumarate. 28 Gastric mucin.. 31 Ferrous gluconate_ 28 Gelatin solution, special intra- Ferrous sulfate_ 28 venous 44 84 ### Page 79 (OCR) 86 62 Levo-Dromoran (levorphanol). 28 Irox (ferrous gluconate). 49 Levarterenol_. 28 Irosul (ferrous sulfate) _ 62 Levallorphan. - 28 Iron oxide, saccharated. 15 Leukeran (chlorambucil) _ 28 Iron dextran complex. 63 Leritine (anilerdine) ... 28 Ircon (ferrous fumarate) _ 10 Lauron (aurothioglycainide). 74 Iproniazid.. Laudanum, see Opium. 66 Ipral (probarbital)_. 58 Larocaine_ - 64 Ipecac_ 67 Largon (propiomazine).. 40 Iothiouracil. 20 Lanoxin (digoxin) - 35 lophenoxic acid_ Lanodoxin (diiodohydroxyquin) _ 35 lophendylate_. Laniazid (isoniazid).- 35 Iopanoic acid.. 58 Lactocaine (procaine) .. 48 Ionamin (phentermine). 47 Lactamin (protein hydrolysate).. 35 Iodopyracet_ 35 Iodophthalein_. 35 Iodomethamate. zine)_ 37 Iodohippurate. Kynex (sulfamethoxypyrida- 5 1 Iodoform. 32 Konayl (plantago ovata coating) - 3 Iodochlorol (chloriodized oil). 41 Konogen (estrogenic substance) - 9, 17 Iodochlorhydroxyquin. 30 Konakion (phytonadione). 35 Iodobrassid_.. 71 Koglucoid (rauwolfia). 35 Iodoalphionic acid. 54 30 Kayquinone (menadione)_. Kemadrin (procyclidine)- 35 41 Iodide solution. Iodized oil.. 30 Kayklot (menadione) - 35 Iodipamide. 65 Kartryl (bromisovalum). 17 Iodine, tincture. 30 Kappaxin (menadione).. 35 Iodeikon (iodophthalein). 4 Kantrex (kanamycin).. 24 Inversine (mecamylamine). 30 Kanone (menadione) .. 34 Inulin. 4 Kanamycin. 55 Intocostrin (chondodendron). K 43 Insulin_. 40 Itrumil (iothiouracil). INH (isoniazid). 20, 50 Isuprel (isoproterenol) - 36 Influenza virus vaccine.. 50 Isoxuprine_.. 41 Inestra (ethinyl estradiol) - 65 Isoval (bromisovalum). 29 Indon (phenindione). 26 Isordil (isorbide dinitrate). 17 Indalone (butapyronoxyl) 26 Isorbide dinitrate. 36 Immune serum globulin.. 20, 50 Isoproterenol_ 75 Imipramine.. 18 Isopropyl alcohol. 28 Imferon (iron dextran complex). 53 Isopropamide_ Ilotycin (erythromycin). 20, 50 Isopro (isoproterenol) - 51 Ilidar (azapetine) - 49 Isophrin (phenylephrine). Isonicop (isoniazid). 5 Isoniazid._ 49 Isometheptene_ 45 Hytakerol (dihydrotachysterol) _ Isolyn (isoniazid).. 36 lin -- 35 Iso-Iodeikon (phentetiathalein). Hyperimmunized gamma-globu- 52 Isofluorophate. 2 G)_. 50 Isoetharine_. Hypercillin (procaine penicillin 74 Isocarboxazid.. 35 Hypaque (diatrizoate) .. 66 Isobarb (pentabarbital). 32 Hykolex (dehydrocholic acid) . 25 Ismelin (guanethidine). 30 bisulfite) - 32 isatin) .. Hykinone (menadione sodium Isacen (diacetyldihydroxypheny)- 22 Hygroton (chlorthalidone). Page Page ### Page 80 (OCR) 85 4б Hyflavin (methylol riboflavin). 66 Hentabarbital. 71 Hydroxyzine_. 28 Heparin sodium_ 12 Hydroxystilbamidine. 28 Heparin repository- 41 Hydroxyprogesterone. 28 Heparin potassium, sublingual. 4 Hydroxyethyl sulfone_ 23 Heparin_.. Hydroxydione.. 28 Hemorate (ferrous fumarate) -. Hydroxychloroquine. 49 28 Hydroxyamphetamine. Hydroxocobalamin. 57 29 Hedulin (phenindione).. Helium_ 31 gel)__ 28 Hed-Heparin (heparin sodium)-. Hydroxal (aluminum hydroxide 39 Heb-Cort (hydrocortisone).. 17 Hydrogen peroxide. 71 Harmonyl (deserpidine).- 22 zide) .. 57 Halothane.. (hydrochlorothia- Hydrodiuril 42 Halotestin (fluoxymesterone) - 39 Hydrocortone (hydrocortisone).. 41 Haloprogesterone_- 39 Hydrocortisone_ 71 Haloperidol... 22 Hydrochlorothiazide. 45 Halibut liver oil.. sterol. H Hydrocalciferol see dihydrotachy- 24 Hydralazine - 27 Gynergan. 2 penicillin. 25 Guanethidine. phenoxymethyl Hydrabamine 8 Guanatol (chlorguanide). 51 loids) . 64 late) __ Hydergine (dihydroergot alka- Guafanesin (glyceryl guaiaco- 39 Hydeltra (prednisolone) - Griseofulvin. 39 Hycortole (hydrocortisone) Grifulvin (griseofulvin)_. 62 Humorsol (demecarium).. 10 Gold sodium thiosulfate. 4 Humatin (paramomycin) - 10 Gold sodium thiomalate_ 44 Human albumin_ 55 Glyotol (mephensin). 47 Homogenized fat preparations. 31 Glycotauro (bile salta)- 53, 54 Homatropine. 10 Glycobiarsol.. 53 Homatromide (homatropine). 26 Glyceryl trinitrate.. 64 Homarylamine.. B4 Glyceryl guaiacolate. 53 lomapin (homatropine). 66 Glutethimide_ 58 Holocaine (phenacaine) 47 Glutavite (sodium glutamate) _ 34 Histamine_ 47 Glutavene (sodium glutamate). 34 Hiatalog (betazole) . 47 Glutamic acid_.. 37 Histadyl (methapyrilene). 47 Glucurone (glucourolactone). 35 Hippuran (iodohippurate) - 47 Glucourolactone_. 24 Hiohex (hexamethonium) Glucosulfone_.. 13 Hexylresorcinol. 47 Glucose_. 58 Hexylcaine. 26 methyl glucamine).- 53 Hexocyclium. Glucophylline (theophylline 57 Hexobarbital. 9 Glaucarubin. 41 Hexestrol_. Glarubin (glaucarubin).. 46 Hexavitamin _ 20 Gitalin_. 24 Hexameton (hexamethonium). 20 Gitalgin (gitalin). 24 Hexamethonium 41 Gestanon (allylestrenol). 29 Hexadimethrine_ 12 Germanin (suramin) .. 17 Hexachlorophene_ 14 Gentran (dextran). Benzene hexachloride. 68 Gemonil (metharbital) - see Hexachlorocyclohexane, 14, 18 Gentian violet_ 14 Hetrazan (diethylcarbamazine).. 31 gel)_.. 62 Heroin.. Gelumina (aluminum hydroxide Page Page ### Page 81 (OCR) Page Page Levophed (levarterenol) 49 Man-Tan (dioxyacetone) 19 Levophenethicillin 2 Mapharsen (oxophenarsine) 10 Levorphanol 62 Marezine (cyclizine) - 38 Levothyroxine, sodium 40 Marplan (isocarboxazid) - 74 Librium (clordiazepoxide) 72 Marsilid (iproniazid). 74 Lidocaine 58 Masenone (methyltestosterone) 42 Lindane, see Benzene hexachlo- Matromycin (oleandomycin) 3 ride. Maxitrate (mannitol hexani- Liothyronine, sodium 40 trate) .. 26 Lipiodol (iodized oil) 35 M-Delphene (dimethyltolumide). 17 Lipo-Heprin (heparin sodium)- 28 Mebaral (mephobarbital). 68 Lipoiodine (iodobrassid) 35 Mecamylamine 24 Lipo-Lutin (progesterone) 42 Mechlorethamine see Nitrogen Lipomul (cottonseed oil emul- mustard. sion)- 47 Mecholyl (methacholine). 52 Liquaemin (heparin sodium)- 28 Meclizine- 38 Liquamar (phenprocoumon) 29 Mecostrin (tubocurarine) 55 Liquid petrolatum 32 Medomin (heptabarbital)- 66 Liquid petrolatum emulsion 32 Medopaque (iodohippurate) - 35 Liquiprin (salicylamide). 60 Medrol (methylprednisolone) 39 Listacort (prednisone) - 39 Medroxyprogesterone. 42 Liver injection 28 Megimide (bemegride) 73 L-Maxipen (levophenethicillin) 2 Mellaril (thioridazine) - 70 Lomotil (diphenoxylate)- 63 Meloxine (methoxsalen) 19 Lorfan (levallorphạn). 62 Menadione. 30 Lotusate (talbutal) - 66 Menadione sodium bisulfate 30 Lucanthone 12 Menagen (estrone) 41 Lucocorteum (progesterone) - 42 Menformin (estrone) 41 Lucorteum (ethisterone)-- 41 Menthol. 18 Lugol's (iodide solution) 41 Meonine (methionine) - 47 Luminal (phenobarbital)- 66, 68 Mepazine- 70 Lunargen (silver protein) 18 Mepenzolate 53 Lutocyclin (progesterone) 42 Meperidine 63 Lutocyclol (ethisterone)- 41 Mephedan (mephenesin). 55 Lutoral (ethisterone) - 41 Mephenesin. 55 Lutrexin (lututrin)- 42 Mephenesin carbamate 55 Lututrin 42 Mephenoxalone 72 Mephentermine- 49 M Mephobarbital 68 Madribon (sulfadimethoxine) 1 Mephyton (phytonadione) 30 Magmasil (magnesium trisili- Mepivacaine. 58 cate)_. 31 Meprobamate. 71 Magnamycin (carbomycin). Meprospan (meprobamate) - 71 Magnesia magma_. 32 Mepyrapone_ 40 Magnesium citrate- 32 MER-29 (triparanol) - 23 Magnesium oxide-. 31 Meractinomycin. 16 Magnesium salta- 57 Meralluride. 21 Magnesium sulfate- 32 Meratran (pipradol) 74 Magnesium trisilicate. 31 Merbromin 18 Malcotran (homatropine).. 58 Mercaptomerin- 21 Mandelamine (methenamine Mercaptopurine- 15 mandelate) _ Mercodinone (dihydracodeinone) - 62 Mannitol_ 34 Mercuhydrin (meralluride) - 21 Mannitol hexanitrate- 26 Mercumatilin 21 87 ### Page 82 (OCR) Page Page Mercuric chloride 18 Methoxsalen 19 Mercuric salicylate. 10 Methoxyflurane. 57 Mercurochrome (merbromin) 18 • Methoxyn (methamphetamine) - 48, 50 Mercurophylline - 21 Methoxyphenamine 49 Mercuzanthin (mercurophylline) - 21 Methoxypromizine 70 Merphylline (mersalyl sodium Methscopolamine 53 and theophylline) 21 Methsuximide - 68 Mersalyl sodium and theophyl- Methylaminoheptane. 49 line_ 21 Methylandrostenediol 42 Mertestate (testosterone). 42 Methylcellulose. 32 Merthiolate (thiomersol) - 18 Methylclothiazide. 22 Mesantoin (N-methylphenyleth- Methyldopa 25 ylhydantoin)- 68 Methyl ergonovine. 27 Mesopin (homatropine) - - 53 Methylhexaneamine- 49 Mestinon (pyridostigmine)- 55 Methylol riboflavin 45 Metamidium 12 Methylparafynol 65 Metamine (trolnitrate)-. 26 Methylphenidate. 74 Metamucil (psyllium hydrophilic Methylprednisolone 39 mucilloid). 32 Methylrosaniline, see Gentian Metandren (methyltestosterone) - 42 violet. Metaphen (nitromersol) 18 Methyl Balicylate, see Oil of Metaphyllin (aminophylline). 21 wintergreen. Metapon. 62 Methylsulfanilamidoisoxazole. 1 Metaraminol 49 Methyltestosterone 42 Metasone (prednisone) 39 Methylthiouracil 40 Methacholine 52 Methyprylon_ 66 Methadone. 63 Meticortelone (prednisolone) 39 Methallenestril 41 Meticorten (prednisone).. 39 Methalone. 42 Metlone (methionine) 47 Methamphetamine. 48, 49, 74 Metopirone (mepyrapone).. 40 Methandrostenolone. 42 Metrazol (pentylenetetrazol). 73 Methantheline 53 Metronidazole. 10 Methapheniline - 37 Metubine (dimethyltubocura Methapyrilene 37 rine) _. 55 Metharbital 68 | Metycaine (piperocaine) - 58 Methazolamide. 22 Mictine (aminometradine) - 22 Methdilazine 37, 70 Mild mercurous chloride. 32 Methedrine (methamphetamine) - 48, 50 Milibis (glycobiarsol)- 10 Methenamine mandelate 5 Milk of magnesia (magnesia Methergine (methyl ergonovine) - 27 magma). 32 Methimazole_ 40 Milontin (phensuximide). 68 Methiocil (methylthiouracil) 40 Miltown (meprobamate) - 71 Methiodal 35 Miokon (diprotrizoate). 35 Methionine 47 Miracil D (lucanthone) - 12 Methitrual. 57 Miradon (anisindone)-. 29 Methium (hexamethonium) - 24 Mitronal (cinnarazine) - 38 Methocarbamol.. 55 Moderil (rescinamine) - 71 Methohexital. 57 Modumate (arginine glutamate) - 47 Methotrexute. Methostan (methylandrostene- diol) .. 42 15 Monase (etryptamine)- Monocaine (butethamine) - Monobenzone. Moebiquin (diiodohydroxyquin). 74 19 58 9 Methoxa-Dome (methoxsalen) 19 Monodral (penthienate). 53 Methoxamine 49 | Mornidine (pipamazine). 70 88 ### Page 83 (OCR) Page Page Penicillamine. Phenazopyridine Б Penicillinase- Phencyclidine. 57 Penicillin G_ Phenelzine- 74 Penicillin O 37, 67 Penicillin V (phenoxymethylpeni- Phenethicillin. 2 cillin) - - 2 Phenformin. 43 Pentabarbital 66 Phenglutaramide 38 Pentaerythritol tetranitrate. 26 Phenindiamine. 37 Pental (pentabarbitol).. 66 Phenindione- 29 Pentapiperide_ 53 Pheniprazine 74 Pentaquine_ Pheniramine 37 Penthamil calcium trisodium Phenmetrazine. 48, 50 Penthienate. 53 Phenobarbital 66, 68 Penthrane (methoxyflurane) - 57 Phenol.. 18 Pentolinium_ 24 Phenolphthalein. 32 Pentothal (thiopental) - 57 Phenol red, Pentrazol (pentylenetetrazol) - 73 phthalein. Pentritol (pentaerythritol tetra- 34 nitrate) 26 51 Pentrolone (pentylenetetrazol) - 73 Pentylenetetrazol - 73 29 Pen-Vee Suspension (phenoxy- Phensuximide. 68 methylpenicillin) .. 2 • Phentermine. 48 Percodan (dihydrohydroxyco- 35 deinone) . 62 Phentolamine. 51 Percomorph liver oil. 45 68 Periactin (cyproheptadine) - 37 Phenylbutazone- 60 Perichlor (petrichloral) 65 Phenylephrine. 49 Periston (polyvinyl pyrrolidone). 44 5 Peritrate (pentaerythritol tetra- 48,49 nitrate) - 26 49 Perizil (chlorcyclizine) - 37 Phenyramidol 61 Permapen (benzathine penicillin 17 G) - 2 Pholcodine 62 Pernoston (butallylonal) - 66 Perolysen (pempidine) -. 24 phate) _. 31 Perphenazine. 70 52 Pertussis immune serum 36 1 Pertussia vaccine. 36 Phyaostigmine 52 Pethidine (meperidine). 63 Phytonadione. 30 Petrichloral. 65 18 Petrogalar (liquid petrolatum Picrotoxin_. 78 emulsion) - 32 Pilocarpine. 52 Petrolatum, see Liquid petro- 54 latum. Pipamazine- 70 Petronol (liquid petrolatum). 32 Phanodorn (cyclobarbital) 66 Pipenzolate_. 53 Phemerol (benzethonium) - 18 Piperacetazine. 70 Phenacaine_. 58 Piperazine.. 14 Phenacemide. 68 41 Phenacetin (acetophenetidin). 60 Piperidolate. 53 Phenaglycodol_ 71 Piperilate - 71 Phenampromide_. Piperocaine. 58 Phenazooine. 62 Piperoxan 51 91 ### Page 84 (OCR) Page Page Pipradol 74 Priscoline (tolazoline) 51 Piptal (pipenzolate). 53 Privine (naphazoline) 49 Pitocin (oxytocin) 27 Pro-Banthine (propantheline).. 53 Pitressin (vasopressin) - 27 Probarbital 66 Placidyl (ethohlorvynol) 65 Probenecid 23 Plague vaccine- 36 Procaine 58 Plantago ovata coating 32 Procaine amide 20 Plaquenil (hydroxychloroquine) - 8 | Procaine penicillin G_. 2 Plasma protein fraction, human 44 Prochlorperazine. 70 Plasmanate (plasma protein frac- Procholon (dehydrocholic acid) 32 tion, human) - Procyclidine 54 Plazmoid (gelatin solution, Prodilidine. 63 special intravenous) . 44 Proferrin (iron oxide, saccharated). 28 Plebilin (bile salts) - 31 Proflavine_ 18 Poldine_ 53 Progesterone. 42 Poliomyelitis immune globulin 30 Progestoral (ethisterone) 41 Poliomyelitia virus vaccine- 36 Progynon (estradiol)... 41 Poloxalkol. 32 Prohalone (haloprogesterone) 41 Polyamine-methylene resin 31 Prolax (mephenein).. 55 Polybrene (hexadimethrine) 29 Prolixin (Huphenazine). 70 Polycarbophil 33 Promacetin (sodium acetogul- Polycyoline (tetracyoline) - fone) - Polyferose 28 Promazine. 70 Polykol (poloxalkol). 82 Promethazine.. 37, 67 Polymyxin B. 6 Promin (glucosulfone) Polythiazide. 22 Promizole (thiazolsulfone).. 4 Polyvinyl pyrrolidone. Promoxolane_ 55 Pontocaine (tetracaine) - 58 Pronestyi (procaine amide) 20 Poquil (pyrvinium) 13 Propadrine (phenyIpropanola- Posterior pituitary - 27 mine).. 28, 49 Potassium bromide. 65 Propantheline. 53 Potassium obloride. 44 Proparacaine- 58 Potassium and magnesium salte Propiomazine_ B7 of aspartic acid. 47 Propoxycaine - 58 Potassium permanganate 18 Propylhexedrine 49 Potassium phenoxymethyl Propyliodone. 35 penicillin 2 Propyithiouraoil 40 Potaasium salts. 21 Prostaphlin (oxacillin) 2 Povan (pyrvinium). 13 Prostigmine (neostigmine)-. 52, 55 Powder of ipecac and opium 62 Protamine_ 29 Powdered opium 62 Protargin (silver protein). 18 Pramoxine 58 Protargol (ailver protein)- 18 Pranone (ethisterone).. $1 Protein hydrolysates. 47 Prantal (diphemanil) - 53 Prothromadin (warfarin) - 29 Prednisolone. 39 Protochylol. 50 Prednisone_ 39 Protoveratrines A & B.. 24 Pregnyl (chorionic gonadotro- Provera (medroxyprogesterone) - 42 pin) - 42 Proxamine. 87 Preludin (phenmetrazine) - 48, 50 Peyllium hydrophilic mucilloid. 82 Premarin (estrogenic substance). 41 Purinethol (mercaptopurine). 15 Primadol (phenazocine) - 62 Puromycin. 16 Primaquine 8 PVP (polyvinyl pyrrolidone). 44 Primidone_. 68 Pyramidon (aminopyrine) - 60 Priodax (iodoalphionio scid) 35 Pyrathiazine 37 92 ### Page 85 (OCR) Page Pago Sumycin (tetracycline). Supranephrin (epinephrine) Suramin_. Surfacine (cyclomethycaine)- - Surfak (calcium-bis-dioctyl sulfosuccinate) _ Terpin hydrate, Elixir, see Elixir 49 terpin hydrate with codeine 12 and similar mixtures. 58 Terramycin (oxytetracycline) Tessalon (benzonatate).. 64 32 Testobase (testosterone) - 42 Surital (thiamylal) - - - 57 Testosterone. 42 Suvren (captodiamine)- 71 Testra (methyltestosterone) 42 Suxinyl (succinylcholine).. 55 Testryl (testosterone) 42 Sycotrol (piperilate) .. 71 Tetanus antitoxin_ 36 Synalar (fluocinolone) 39 Tetanus toxoid 36 Synandrol (testosterone) - 42 Tetrabenazine. 71 Synasal (phenylephrine)- 49 Tetrabon (tetracycline) - 3 Synate (aecobarbital) - 66 Tetracaine 58 Syncillin (phenethichllin) - 2 Tetrachlorethylene. 13 Syncort (desoxycorticosterone).. 39 Tetracycline_ 3 - Syncurine (decamethonium). 55 Tetracyn (tetracycline) 3 Syngesterone (progesterone) - 42 Tetraethylammonium 24 Syntetrin (rolitetracycline) - 3 Tetrahydrozoline- 49 Synthetic oleovitamin D 45 Tetrex (tetracycline). 3 Synthroid (levothyroxine, sodi- Theedol (estriol) . 41 um) - 40 Theelin (estrone) 41 Syntocinon (oxytocin) 27 Thelestrin (estrone)-. 41 Syntropan (amprotropine)- 53 Thenalidine. 37 Syrosingopine. 24 Thenfadil (thenyldiamine). 37 Syrup of ipecac. 31 Thenyldiamine. 37 Syatiral (chlorphenoxamine) - 37 Theoglycinate (theophylline s0- dium glycinate) . 26 T Theophylline - 21 Theophylline methyl glucamine 26 Tacaryl (methdilazine) 37, 70 Theophylline sodium glycinate 26 Tace (chlorotrianisene) 41 Thephorin (phenindiamine)- 37 Tagathen (chlorothen) - 37 Thiamine_. 40 Talbutal - 66 Thiamylal 57 Tandearil (oxyphenbutazone)- 60 Thiazolsulfone. 4 TAO (triacetyloleandomycin) 3 Thiethylperazine 70 Tapazole (methimazole) -. 40 Thioban (thiocarbanidin) .. 5 Taractan (chlorprothixine) - 70 Thiocarbanidin. 5 Tartar emetic, see Antimony Thiomerin (mercaptomerin) .. 21 potassium tartrate. Thiomersol. 18 Tebamin (phenyl-p-aminosali- Thiopental_. 57 cylate) - Thioperazine. 70 Tefron (polyferose) -. Thiopropazate. 70 Telepaque (iopanoic acid) _. 35 Thioridazine_ 70 TEM (triethylenemelamine). 15 Thiosulfil (sulfamethizole)-- 1 Temaril (trimeprazine)-. 70 Thiotepa_ 15 Tempra (acetaminophen)- 60 Thiouracil. 40 Tensilon (edrophonium)- 55 Thiourea.-- 40 Tentone (methoxypromazine)- 70 Thonzylamine. 37 Tepanil (diethylpropion) - - 48 Thorazine (chlorpromazine)-. 70 Teridax (iophenoxic acid) -. 35 Thrombolysin (fibrinolysin)- 29 Tergitol (sodium tetradecyl sul- Thylogen (pyrilamine maleate)_. 37 fate)_ 19 | Thyloquinone (menadione) - 30 95 ### Page 86 (OCR) Page Page Thymol 18, 18 Trimethobenzamide 70 Thyroid 40 Trimeton (phenirmaine) 37 Thyrotropic acid - 23 Trinesium (magnesium tribili- Thyroxin.. 40 cate) . 31 Tibione (amithiozone) - 5 Triopron (thyrotropic soid).. 23 Tigan (trimethobenzamide). 70 Triparanol. 23 Tincture of opium, see Opium. Tripellenamine- 37 Tindal (acetophenazine). 70 Triprolidine. 37 Toclase (carbetapentane). 64 Trisomin (magneslum trisilicate). 81 Tofranil (imipramine). 75 Trolnitrate_ 26 Tolansin (mephenesin) - 55 Tromexan (ethylbiacoumacetate) 29 Tolazoline. 51 Tronothane (pramoxine) - 58 Tolbutamide_ 48 Tropicamide. Toleron (ferrous fumarate) - 28 Trypareamide_ 10 Tolonium 29 Trypsin- 20 Toloxychlorinol.. 65 Tryptar (trypsin) - 20 Toloxyn (mephensin) _. 55 Tryptest (trypsin). 29 Tolseram (mephenesin car- Tuamine (tuaminoheptane) - 49 bamate). 55 Tuaminobeptane 40 Tolserol (mephenesin). 55 Tubadil (tubocurarine). 55 Tolysin (neocincophen) - 61 Tubarine (tubocurarine) 55 Torecan (thiethylperazine) - 70 Tuberoulosis vaccine. 36 Toryn (caramiphen) .. 54 Tubocurarine 55 Tral (hexocyclium). 53 Tylenol (acetaminophen) 60 Trancopal (chlormezanone) - 56 Tylosin _ Tranyloypromine__ 74 Typhoid and paratyphoid vac- Trasentine (adiphenine). 53 cine_ 36 Travamin (protein hydrolysate). 47 Typhua vaccine. 36 Trecator (ethionamide) - 5 Tyrosinone (ethlaterone) - Trepidone (mephenoxBlone) 72 Tyrothricin 6 Triacetin_ 18 Tyvid (isoniazid). Triacetyloleandomy cin. 3 Tyzine (tetrahydrozoline) 49 Triamcinolone. 39 Triaeyn B. 46 U Tribromethanol. 57 Triburon (triclobisonium) 19 Ulacort (prednisolone) 39 Trichlormethiazide 22 Ultran (phenaglycodol) 71 Triclobisonium_. Trichloroethylene- 57 19 Unsaturated fatty acids. Ultrandren (fluoxymesterone). 42 23 Tricyclamol_ 53 Uracil mustard. 15 Tridihexethyl... 53 Urea_-- 21 Triethylenemelamine Tridione (trimethadione).. 68 15 Urecholine (bethanechol) - Urethane_. 52 16 Trifluoperazine. 70 Urokon (acetotrizoate) - 35 Triflupromazine 70 Trifluroethylvinyl ether. 57 V Trihexlphenidyl.. 54 Trilafon (perphenazine) -. 70 Valethamate 53 Trilene (trichloroethylene). Trimethadione. Trimeprazine- Trimax (magnesium trisilicate) - 68 57 81 70 Valpin (octatropine) .. Valnoctamide. Valmid (ethinamate).- Vallestril (methallenestril).. Vancomycin_ 41 65 71 53 3 Trimethaphan 24 Vancosin (vancomycin) - 3 96 ### Page 87 (OCR) 12. ALIMENTARY AGENTS-Continued Page Emetics 31 Choleretics. 31 Cathartics: Lubricants, softeners and bulky substances. 32 Cathartics: Saline, vegetable and other 32 Agents to control diarrhea. 38 13. DIAGNOSTIC AGENTS.. 34 Plasma and blood volume agents. 34 Gastric acidity agents 34 Kidney and liver function agents. 34 Radio opaque media.. 35 Other diagnostic agents 35 14. AGENTS FOR IMMUNOLOGY AND ALLERGY. 36 Toxins and toxoids. 36 Vaccines 36 Immune sera. 36 Allergenic and diagnostic preparations. 37 Antihista mines 37 Antimotion sickness agente 38 15. HORMONES 39 Adrenal mineral corticoida. 39 Adrenal glucosteroids. 39 Adrenal cortical hormone antagonista 40 Corticotropin. 40 Thyroid preparations 40 Antithyroid substances 40 Iodides _ 41 Estrogena 41 Progestins_ 41 Nonsteroid luteal factors. 42 Androgens- 42 Gonadotropins 42 Insulins 43 Insulin substitutes. 43 Parathyroid. - 43 16. BLOOD, FLUIDS AND ELECTROLYTES. 44 Blood and blood products. 44 Plasma subatitutes - 44 Inorganic salta. 44 17. VITAMINS. 45 Vitamin A 45 Vitamin B members and related substances 45 Vitamin C 45 Vitamin D and related ateroida.. 45 Vitamin E 48 Polyvitamin preparations - 46 18. AGENTS IN NUTRITION. 47 Nutritional supplements, carbohydrate- 47 Nutritional supplements, protein and amine acid 47 Nutritional supplemente, fat. 47 Agents in obesity - 48 19. SYMPATHETIC STIMULANTS 49 Vasoconatrictors- 49 Central stimulants. 49 Smooth muscle relaxants 50 ### Page 88 (OCR) Page 20. SYMPATHETIC DEPRESSANTS 51 Vasodilators and hypotensives- 51 21. PARASYMPATHETIC STIMULANTS. 52 Parasympathetic stimulants, direct-. 52 Parasympathetic stimulants, anticholinesterase. 52 22. PARASYMPATHETIC DEPRESSANTS. 53 Antispasmodice 53 Cycloplegice and mydriatics. 54 Central depressanta and antiparkinson agenta. 54 23. MYONEURAL AGENTS. 55 Muscle relaxants, curare type-. 65 Muscle atimulanta. 65 Muscle relaxants, mephenesin type_.. 55 Muscle relaxanta, others. 56 24. ANESTHETICS AND THERAPEUTIC GASES. 57 Inhalation anesthetica. 57 Nonvolatile anesthetics 57 Therapeutic gases. 57 Local anesthetics, injection or topical. 58 Local anesthetics, topical only-. 25. NON-NARCOTIC ANALGESICS Salicylates- 60 Aniline derivatives.. 60 Pyrazolon derivatives_ 60 Colchicine group- 61 Others. 61 26. NARCOTIC ANALGESICS. 62 Opium derivatives- 62 Morphine derivatives and antagonista_ 62 Codeine derivatives 62 Methadone group 63 Meperidine group- 83 27. ANTITUSSIVES. Phenampromide derivatives. 80680088 Expectorante Nonnarcotic suppressives **28. SEDATIVES AND HYPNOTICS.** Halogenated hydrocarbons Bromides_ Paraldehyde. Ureides, carbamates, higher alcohola … 65 Barbiturates, short and intermediate acting- 66 Barbiturates, long soting- 66 Glutethimide group 66 Antihistamine eedatives 87 29. ANTICONVULSANTS 68 Barbiturate group-- 68 Hydantoina. 68 Oxazolidones Other anticonvulsants- **30. TRANQUILIZERS..** Phenothiazine group-. Antiemetics ### Page 89 (OCR) **8. TROPICAL AGENTS** INSECTICIDES benzyl benzoate chlorophenothane (DDT) crotamiton (Eurax) lindane (benzene hexachloride; hexachlorocyclohexane) Undesirable effects in aviation: Local irritation; DDT and lindane may produce irritability, numbness and tingling, tremors, and later, convulsions and death in excessive dosage. Use in aviation personnel: Airman duties not contraindicated after customary topical application and dosage. Medical examination indicated before return to duty. INSECT REPELLANTS butapyronoxyl (Indalone) dimethylphthalate dimethyltolumide (m-Delphene) ethohexadiol (Rutgers 612) Undesirable effects in aviation: Local irritation; little chance of systemic effects. Use in aviation personnel: Airman duties not contrindicated after customary application. Medical examination indicated before return to duty. ANTISEPTICS: PHENOLS, METALS, HALOGENS, OXI- DIZING AGENTS, ALCOHOLS, DYES acriflavine ammoniated mercury bismuth tribromphenate (Xeroform) boric acid cresol ethy. alcohol hexachlorophene (Gamophen; pHisohex) hydrogen peroxide iodine, tincture iodochlorhydroxyquin (Enterokin; Enteroquinol; Quinambicide) iodoform 17 ### Page 90 (OCR) isopropyl alcohol menthol merbromin (Mercurochrome) mercuric chloride methylrosaniline (gentian violet) nitromersol (Metaphen) oil of cloves oil of eucalyptus phenol potassium permanganate proflavine resorcinol scarlet red silver nitrate silver picrate (Picragol) sodium hypochlorite sodium perborate strong and mild silver protein (Argyn; Argyrol; Lunargen; Protargin; Protargol; Silvol) thiomersol (Merthiolate) thymol yellow mercuric oxide zinc oxide Undeglrable effects in aviation: Relatively nontoxic. Some may be irritating (tincture of iodine) ; some sensitizing (ammoniated mercury); some capable of producing systemic toxicity if applied excessively or on abraded skin (phenol). Use in aulation personnel: Airman duties not contraindicated after topical use in conventional dosage. FUNGICIDES benzoic acid caprylic compound (Naprylate) caprylic salts salicylanilide salicylic acid triacetin (Enzactin) Undesirable effects in aviation: Relatively nontoxic. Use in aviation personnel: Airman duties not restricted after topical use in conventional dosage. SURFACE ACTIVE COMPOUNDS benzalkonium (Zephiran) benzethonium (Phemerol) 18 ### Page 91 (OCR) 34 the agents themselves. Use in aulation personnel: Airman duties not contraindicated by Undesirable effects in aviation: Adverse effects unlikely. sulfbromphthalein (Bromthalein) sodium thiosulfate sodium indigotindisulfonate sodium p-amminohippurate phenolsulfonphthalein (phenol red) mannitol inulin galactose benzoic acid KIDNEY AND LIVER FUNCTION AGENTS hours after use. Use in aviation personnel: Airman duties contraindicated for 12 tion from histamine. Undesirable effects in aviation: Transistory flushing and palpitaquinine carbacrylic resin (Diagnex) histamine betazole (Histalog) azuresin (Diagnex blue) GASTRIC ACIDITY AGENTS tic reasons would ordinarily preclude it for at least 24 hours. from the use of these drugs themselves, but medical or diagnos- Use in aviation personnel: Airman duties not contraindicated effects. Undesirable effects in aviation: Unlikely to produce adverse sodium radiochromate radio-iodinated serum albumin radioactive chromic chloride Evans blue **PLASMA AND BLOOD VOLUME AGENTS** **13. DIAGNOSTIC AGENTS** ### Page 92 (OCR) **17. VITAMINS** VITAMIN A carotene in oil cod liver oil halibut liver oil oleovitamin A percomorph liver oil vitamin A Undesirable effects in aviation: Unlikely in adults. Use in aviation personnel: Airman duties not contraindicated by treatment with usual dosage. VITAMIN B MEMBERS AND RELATED SUBSTANCES choline dried yeast methylol riboflavin (Hyflavin) niacin (nicotinic acid) niacinamide (nicotinic acid amide) pantothenic acid pyridoxine riboflavin thiamine Undesirable effects in aviation: Nil except for immediate flushing from niacin. Use in ablation personnel: Airman duties not contraindicated except for 4 hours after the use of doses of niacin which produce any side effects. VITAMIN C ascorbic acid Undesirable effects in aviation: Unknown. Use in aviation personnel: Airman duties not contraindicated during use. VITAMIN D AND RELATED STEROIDS calciferol dihydrotachysterol (Hytakerol; formerly hydrocalciferol) fish liver oils synthetic oleovitamin D 45 ### Page 93 (OCR) Undesirable effects in aviation: Excessive dosage may produce hypercalcemia with anorexia and loss of weight. Use in aviation personnel: Airman duties not contraindicated by antirachitic dosage. Doses over 50,000 i.u. (vitamin D), or 1 ml. dihydrotachysterol daily contraindicate work during the first 2 months of therapy; work thereafter may be permitted in some positions when the blood calcium is adequately stabilized and no symptoms are present. VITAMIN E alpha tocopherol Undesirable effects in aviation: Unknown. Use in aviation personnel: Airman duties not contraindicated by use. POLYVITAMIN PREPARATIONS dried yeast hexavitamin triasyn B wheat germ Undesirable effects in aviation: Unlikely. Use in aviation personnel: Airman duties not contraindicated by use. ### Page 94 (OCR) **24. ANESTHETICS AND THERAPEUTIC GASES** INHALATION ANESTHETICS chloroform cyclopropane ether ethyl chloride ethylene halothane (Fluothane) methoxyflurane (Penthrane) nitrous oxide trichloroethylene (Trilene) trifluoroethylvinyl ether (Fluormar) vinyl ether (Vinethane) Undesirable effects in aviation: Nausea and vomiting during recovery; arrhythmias, liver damage (chloroform). Use in aviation personnel: Airman duties contraindicated for 72 hours after use (24 hours after nitrous oxide if examination shows no sequellae). NONVOLATILE ANESTHETICS herobarbital (Evipal; Evipan; Sombulex) hydroxydione (Viadril) magnesium salts methitural (Neraval) methohexital (Brevital) phencyclidine (Sernyl) thiamylal (Surital) thiopental (Pentothal) tribromethanol (Avertin) Undesirable effects in aviation: Recurrent sleepiness after partial recovery. Use in aviation personnel: Airman duties contraindicated for 48 hours after use. THERAPEUTIC GASES carbon dioxide helium oxygen 57 ### Page 95 (OCR) Undesirable effects in aviation: Local irritation and fatigue remaining after use. Use in aviation personnel: Airman duties contraindicated for 48 hours after therapeutic use. However, it is to be noted that oxygen, properly used, is of advantage to normal airmen in high-altitude flying. LOCAL ANESTHETICS, INJECTION OR TOPICAL benoxinate (Dorsacaine) butacaine (Butyn) butethamine (Monocaine) chlorprocaine (Nesacaine) cocaine cyclomethycaine (Surfacaine) dibucaine (Nupercaine) hexylcaine (Cyclaine) lidocaine (Xylocaine) mepivacaine (Carbocaine) naepaine (Amylsine) piperocaine (Metycaine) procaine (Lactocaine; Neocaine; Novocaine; Scurocaine) proparacaine (Ophthaine) propoxycaine (Ravocaine) tetracaine (Pontocaine) Undesirable effects in aviation: Local discomfort during recovery. Excitement and possible convulsions from overdosage. Use in avlation personnel: Airman duties contraindicated for 12 hours after use. LOCAL ANESTHETICS, TOPICAL ONLY amydricaine (Alypin) benzyl alcohol butylaminobenzoate (Butesin) dimethisoquin (Quotane) diperodon (Diothane) dycyclonine (Dyclone) ethylaminobenzoate (Benzocaine) ethyl chloride eugenol larocaine orthoform (Orthocaine) phenacaine (Holocaine) pramoxine (Tronothane) 58 ### Page 96 (OCR) Undesirable effects in aviation: Moderate depression from large therapeutic doses. Use in aviation personnel: Airman duties contraindicated for 12 hours after use. METHADONE GROUP dextromoramide (Dimorlin; Palfium) dextropropoxyphene (Darvon) methadone (Amidone; Dolophine) Undesirable effects in aviation: Nausea, depression, slowed respiration. Use in aviation personnel: Airman duties contraindicated, for 24 hours after use. In most instances the medical condition would preclude duty for an additional period. MEPERIDINE GROUP alphaprodine (Nisentil) anileridine (Leritine) diphenoxylate (Lomotil) ethoheptazine (Zactane) meperidine (Demerol; Pethidine) prodilidine Undesirable effecta in aviation: Nausea, depression, slowed respiration. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. PHENAMPROMIDE DERIVATIVES diampromide phenampromide Undesirable effects in aviation: Sedation. Use in aviation personnel: Airman duties contraindicated for 12 hours after use. ### Page 97 (OCR) **27. ANTITUSSIVES** EXPECTORANTS ammonium chloride glyceryl guaiacolate (Guaianesin) ipecac sodium iodide Undesirable effects in aviation: Serious side effects unlikely. Use in aviation personnel: Airman duties not contraindicated by use. NONNARCOTIC SUPPRESSIVES benzonatate (Tessalon) carbetapentane (Toclase) chlorphendianol (Detigon) dimethoxanate (Clothera) homary lamine noscapine (Nectadon) Undesirable effects in aviation: Occasional mild nausea, dizziness, drowsiness. Use in aviation personnel: Airman duties not contraindicated by usual dose. ### Page 98 (OCR) **31. STIMULANTS** NIKETHAMIDE GROUP ethamivan (Emivan) nikethamide (Coramine; Nikorin) Undesirable effects in aviation: Toxicity minor; extra-therapeutic doses convulsive. Use in aviation personnel: Airman duties contraindicated by the use of the drug per se for 48 hours. Medical indication would usually preclude duty for a longer period. OTHER MEDULLARY STIMULANTS amiphenazole (Daptazole) bemegride (Megimide) pentylenetetrazol (Cardiazol; Metrazol; Pentrazol; Pentrolone) pierotoxin Undesirable effects in aviation: Strong respiratory stimulation, convulsions. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. However, medical status would presumably preclude duty. REFLEX STIMULANTS ammonium carbonate aromatic spirit of ammonia Undesirable effects in aviation: Effects minor. Use in aviation personnel: Airman duties not contraindicated by use per se, but medical need would probably indicate unfitness for duty. ### Page 99 (OCR) **32. PSYCHIC STIMULANTS** XANTHINE GROUP caffeine coffee; tea, and other beverages containing xanthines Undesirable effects in aviation: Wakefulness, tremor, indigestion, nervousness. Use in aviation personnel: Airman duties not contraindicated by beverage use, but medicinal use would probably indicate unfitness for duty. SYMPATHOMIMETIC GROUP amphetamine (Amitrene; Amphedrine; Benzedrine) dextroamphetamine (Adrizine; Am-Dex; Dadex; Dexedrine) methamphetamine (Desoxyn) Undesirable effects in aviation: Wakefulness, nervousness, impaired judgment. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. DIPHENYLMETHANE GROUP deanol (Deaner) methylphenidate (Ritalin) pipradol (Meratran) Undesirable effects in aviation: Irritability, hyperexcitability, insomnia. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Medicinal need would probably indicate unfitness for duty. AMINE OXIDASE INHIBITORS etryptamine (Monase) iproniazid (Marsilid) isocarboxazid (Marplan) nialamide (Niamid) phenelzine (Nardil) pheniprazine (Catron) (withdrawn) tranylcypromine (Parnate) 74 ### Page 100 (OCR) Page Page Vanquin (pyrvinium) 13 Vonedrine (phenyipropylmethyl- Vaponephrin (racephedrine) - 49 amine) - 49 Varidase (streptokinase-strepto- Vontil (thioperazine) 70 dornase) _ 29 Vasimid (tolazoline) - 51 W Vasodilan (isoxuprine) - 50 Warfarin 29 Vasodilatol (pentaerythritol tet- Wheat germ_ 46 ranitrate) - 26 Whole blood 42 Vasodrine (epinephrine) - 49 Winatrol (stanozolol) - 42 Vasopressin 27 Wyacort (methylprednisolone) 39 49 Wyamine (mephentermine). 49 V-Cillin (phenoxymethylpenicillin) - 2 Velban (vinblastine) - 16 Xanthines. 74 Veralba (protoveratrines A & B). Veriloid (alkavervir) 24 Xeroform (bismuth, tribromphe nate 17 Veronal (barbital) - 66 Aylocaine (lidocaine) - 58 Vesprin (triflupromazine) - 70 | Xylometazoline- 49 Versenate, see Edathamil calcium-disodium. Y Viadril (hydroxydione) - 57 Yatren (chiniofon). Vinactane (viomycin) - 4 Yellow fever vaccine_ 36 Vinbarbital 66 Yellow mercuric oxide 18 Vinblastine 16 Yodoxin (diiodohydroxyquin) - 9 Vinethane (vinyl ether) - 57 Vinyl ether -57 Vioform (iodochlorhydroxyquin) - Zactane (ethoheptazine). 63 Viomycin Zanchol (florantyrone) - 32 Vio-Serpine (rauwolfia) 71 Zarontin (ethosuximide) - 68 Vistaril (hydroxyzine) - 71 Zephiran (benzalkonium)- 18 Vitamin A. 45 Zinc oxide.. 18 Vitamin B, (cyanocobalamin) - 28 Zine sulfate_ 31 Vitamin K, oxide. 30 Zoxazolamine 23, 56 97 * U. S. COVERNMENT PRINTING OFFICE : 1966 O - 274-949 ### Page 101 (OCR) 90 26 trate)_. 26 Oxytriphylline_ Pencard (pentaerythritol tetrani- 27 : Oxytocin__ 2 Penbritin (ampicillin).. Oxytetracycline_ 24 Pempidine... 53 Oxyphenonium_. 66 Pembule (pentabarbital). 53 Oxyphencyclimine_. 13 Pelletierine. 60 Oxyphenbutazone- 68 Peganone (ethotoin)- 62 Oxymorphone__.. 33 Pectin_- 42 Oxymetholone- 26 Paveril (dioxyline)_. 39 Oxylone (fluoxolonate). 53 Pavatrine_. 57 Oxygen. -. 53 Pathilon (tridihexethyl) _ 32 Oxycholin (dehydrocholic acid). 5 Pasara (para-aminosalicy lic acid). 14 Oxucide (piperazine).. 54 Parsidol (ethopropazide). 19 OxBoralen (methoxsalen) - 4 Paromomycin.. 10 Oxophenarsine_. 74 Parnate (tranylcypromine). 32 Ox bile extract.. 29 Parenzyme (trypsin). 71 Ozanamide_ 33, 62 Paregorio_.. Oxamycin (cycloserine) - 49 mine)_. 2 Oxacillin__ (hydroxyampheta- Paredrine 41 Ovocyclin (estradiol) _ 43 Parathyroid injection_ 20 Ousbain__ 43 jection)_. 49 Otrivin (xylometazoline) - Parathormone (parathyroid in- 49 Orthoxine (methoxyphenamine). 5 acid)_. 58 Orthoform_. (para - aminosalicylic Parasal 58 Orthocaine (orthoform). 5 acid)_ 54 Orphenadrine.. Parapas (para - aminosalicylic Orisul (sulfaphenazole). 1 Para-nitrosulfathiazole_. 43 Orinase (tolbutamide) _ 68 Paramethadione_. 42 Orgasteron (normetandrone). 65 Paraldehyde_ 42 Oreton-M (methyltesterone). 56 Paraflex (chlorzoxazone). 42 Oreton-F' (testosterone)_. 68 Paradione (paramethadione). 22 Oretic (hydrochlorothiazide). 39 Paracort (prednisone). 41 Orestralyn (ethinyl estradiol). 5 Para-aminosalicylic acid. 29 Orenzyme (trypsin) .. 27 Papaverine_ 42 Ora-Testryl (fluoxymesterone). 29 Panwarfin (warfarin)_ 55 Oranixon (mephenesin). 45 Pantothenic acid... 41 Ora-Lutin (ethisterone) - 62 Pantopon_ 35 Orabilex (bunamiodyl) - 35 Pantopaque (iophendylate). 33, 62 Opium_. 54 Panparnit (caramiphen). 58 Opthaine. Panmycin (tetracycline). 45 Oleovitamin A. 29 Pancreatio dornase_ Oleandomycin. 49 mine) _-- 60 Oll of wintergreen- (phenylpropanola- Panamine 18 Oil of eucalyptus_ acid)_. 18 Oil of cloves_. Pamisy) (para - aminosalicylic 14 Oil of chenopodium_ 53 Pamine (methscoplamine) -. 49 Oenethyl (methylaminoheptane) Pamaquine_ 26 Octyl nitrite_. 8 Paludrine (chlorguanide). 26 | Octrite (octyl nitrite) - 63 Palfum (dextromoramide). 41 Octofollin (benzestrol). 54 Pagitane (cycrimine) -- 49 Octin (isometheptene) - 70 Pacatal (mepazine).. 53 Octatropine.. Page Page Pr ### Page 102 (OCR) 89 Nystatin_ 52, 55 Neostigmine... 50 Nylidrin_. 42 dil) _. Nydrazid (isoniazid).. Nuprin (sulfamoxole). 12 58 Nupercaine (dibucaine) _ 4 Neomycin.. 65 62 Numorphan (oxymorphone).. Nuncital (emylcamate). 40 32 Nujol (liquid petrolatum). 68 N-phenylbarbital. 35 58 Novocaine (procaine). 21 Novobiocin_. 42 41 Novestrol (ethinyl estradiol). 37 53 Novatrin (homatropine) ... 42 65 Nostyn (ectylurea) - 61 Neocincophen.. 64 Noscapine. 58 48, 50 Norodin (methamphetamine). 10 42 Normetandrone_ 37 ate) .. 14 Normal human plasma.. 42 Norlutin (norethindrone) .. 66 42 Norethynodrel. 64 42 Norethindrone_ 22 I 42 Norethandrolone. 32 cellulose)_. 49 Nordefrin 66 Nodular (methyprylon) - 74 68 N-methylphenylethylhydantoin. 22 32 emulsion) _ 18 Nivea cream (liquid petrolatum 12 Nitrous oxide_ 49 Naphazoline_. Nitromersol. 66 i Nitrogen mustard. 42 Nandrolone_. Nitrofurazone__ 62 Nalorphine_. Nitrofurantoin_ 62 Nitoman (tetrabenazine) . 58 Naepaine. _ zole) _. 53 Nisulfazole (para-nitrosulfathia- 42 Nisentil (alphaprodine). Nionate (ferrous gluconate) - N quin) .. Nioform (iodochlorhydroxy- 55 Mytolon (benzoquinonium). 42 Nilevar (norethandrolone) _ 52, 55 Mytelase (ambenonium) - 73 Nikorin (nikethamide) .. 68 Mysoline (primidone).. 73 Nikethamide__ 26 Myodil (amotriphene) - 45 Nicotinic acid amide_. 10 malate) _ 23, 45 Nicotinic acid... Myochrysine (gold sodium thio- 74 Niamid (nialamide) _. 15 Myleran (bisulfan). 74 Nialamide. 54 Mydriacyl (tropicamide) - amide. Mycostatin (nystatin).. Niacinamide, see Nicotinic acid 4 Mycifradin (neomycin).. Niacin, see Nicotinic acid. 55 Myanesin (mephenesin) _. 2 Neutrapen (penicillinase).. 15 Mustargen (nitrogen mustard)_. 58 Nesacaine (chlorprocaine). 53 Murel (valethamate)_.. 57 Neraval (methitural) _ 40 Muracil (methylthiouracil). 22 Neptazane (methazolamide) - 36 Mumps virus vaccine- 49 Ncosynephrine (phenylephrine).. 62 Morphine. Page Page ### Page 103 (OCR) **26. NARCOTIC ANALGESICS** OPIUM DERIVATIVES camphorated tincture of opium (paregoric) pantopon powdered opium powder of ipecac and opium (Dover's powder) tincture of opium (laudanum) Undesirable effects in aviation: Sleepiness from excessive dosage. Use in aviation personnel: Airman duties contraindicated for 12 hours after use. MORPHINE DERIVATIVES (AND ANTAGONISTS) apomorphine dihydromorphinone (Dilaudid) heroin levallorphan (Lorfan) levorphanol (Levo-Dromoran) metapon morphine nalorphine (Nalline) oxymorphone (Numorphan) phenazocine (Primadol) Undesirable effects in aviation: Nausea, vomiting, colic, general depression, slowed respiration, vasomotor depression. Use in aviation personnel: Airman duties contraindicated for 24 hours after use. In most instances the medical condition would preclude work for an additional period. CODEINE DERIVATIVES codeine dextromethorphan (Romilar) dihydrocodeinone (Codone; Dicodid; Mercodinone) dihydrohydroxycodeinone (contained in Percodan) drocode (Didrate) elixir terpin hydrate and codeine and similar mixtures ethyl morphine (Dionin) pholcodine (Ethnine) 62 ### Page 104 (OCR) Use in avlation personnel: Airman duties not contraindicated in the absence of adverse effects; however, patient should be under close observation for blood changes. COLCHICINE GROUP colchicine demecolcine (Colcemid) Undesirable effecta in aviation: Purging at upper therapeutic levels. Use in aviation personnel: Airman duties contraindicated for 48 hours after use. OTHERS cinchophen (Atophan) neocincophen (Tolysin) phenyramidol (Analexin) Undesirable effects in aviation: The cincophens may produce hepatitis; phenyramidol causes infrequent gastrointestinal distress and pruritis. Use in avlation personnel: Airman duties not contraindicated in the absence of adverse effects. Medical examinations indicated at 2-week intervals if therapy continuous. ### Page 105 (OCR) Page Page Pyrazinamide Restrol (dienestrol). 41 Pyribenzamine (tripellenamine). Rhubarb 32 Pyrictal (N-phenylbarbital) - Riboffavin _ 45 Pyridium (phenazopyridine) - Rimifon (isoniazid) Pyridostigmine. Ristocetin 3 Pyridoxine - 45 Ritalin (methylphenidate). 74 Pyrilamine maleate. 37 Robalate (dihydroxyaluminum Pyrimethamine 8 amino acetate) 31 Pyronil (pyrrobutamine) - 37 Robaxin (methocarbamol) - 55 Pyrrobutamine_ 37 Rolicton (amisometradine) 22 Pyrrolazote (pyrathiazlne)_. 37 Rolitetracycline_. 3 Pyruvic acid Isonicotinyl hydra- Romilar (dextromethorphan) . 62 zone_ Roxinold (reserpine). 24, 71 Pyrvinium 13 Rutgers 612 (ethohexadiol) 17 Rythritol (pentaerythritol tetranitrate) 26 Quelicin (succinylcholine) - 55 Quiactin (oxanamide) _. 71 Quide (piperacetazine) - 70 Saff (safflower oil) 23 Quilene (pentapiperide) 53 Safflower oil. 23 Quinacrine. 8, 13 Saffola (safflower oil) - 23 Quinadone (dilodohydroxyquin). 9 Saffolin (safflower oil) - 23 Quinambicide (lodochlorhyd- Salam/de (salicylamide). 60 roxyquin) 9, 17 Salazopyrin (salicylazosulfapy- Quinidine 20 ridine) - 2 Quinine Salicin (salicylamide). 60 Quinine and urea hydrochloride. 59 Salicyl (magnesium trisilicate) 31 Quinine carbacrylio resIn 34 | Salicylamide 60 Quotane (dimethisoquin) 58 Salicylanilide 18 Salicylazosulfapyridine 2 R Salicylic acid 18, 60 Rabies vaccine 36 Saligenin 59 Racephedrine. 49 Salrin (salicylamide) 60 Radloactive chromic chloride. 34 Salvarsan (arsphenamine) - 10 Radioactive vitamin B13- 35 Salyrgan theophylline (mersalyl Radio-iodinated serum albumin. 84 sodium and theophylline) 21 Raudixin (rauwolfia) 71 Sandoptal (allybarbituric acid) - 86 Raulon (rauwolfia) - 71 Sandostene (thenalidine) 37 Rau-Sed (reserpine) - 24, 71 Sandril (reserpine) 71 Rau-Tab (rauwolfia) _ 71 Santonin. 14 Rautensin (rauwolfs) - 71 Sarcolysin. 15 Rauwiloid (alseroxylon) - 71 Saxol (liquid petrolatum) 32 Rauwolfia group - 24 Scarlet fever immune serum 36 Rauwolfia. 71 Scarlet red 18 Ravocaine (propoxycaine) - 68 Scopolamine б4 Regitine (phentolamine).. 51 Scurocaine (procaine) - 58 Relaxin_. 42 Secobarbital 66 Renese (polythiazide) - 22 Seconal (secobarbital) 66 Renstamin (pyrilamine maleate) - 37 Sedormid (allylispropylacetylcar- Rescinamine. 71 bamide) - 66 Reserpine 24, 71 Senna _ 32 Reserpoid (reserpine) - 24, 71 Serfin (reserpine).--. 24, 71 Resorcinol 18 | Bernyl (phencyclidine) - 57 93 ### Page 106 (OCR) Page Pape Serpasil (reserpine) - 24, 71 Spiramycin 3 Serpiloid (reserpine) 24, 71 Spironolactone. 22 Sethyl (homatropine) - Serpine (reserpine) - 71 53 Stanolone Spontin (ristocetin) 42 3 Silver nitrate 18 Stanozolol 42 Silver pierate_ 18 Staphcillin (sodium methicillin) - 2 Silver protein 18 Staphylomycin 3 Silvol (silver protein) - 18 Steclin (tetracycline) - 3 Sinan (mephenesin)- 55 Stelazine (trifluoperazine) - 70 Sinaxar (styramate) 55 Stenediol (methylandrostene- Singoserp (syrosingopine) - 24 diol)_ 42 Sintrom (acenocoumarin) 29 Stibophen 12 Sitosterols. 23 Stigmonene (benzpyrinium). 52, 55 Skin test antigens- 37 Stilbamidine. 12 Skiodan (methioda!) 35 Stilbamine glucoside. 12 Smallpox vaccine. 36 Stilbestrol (diethyletilbestrol) 41 Soap- 19 Stramonium 54 Sodium acetosulfone 4 Streptokinase-streptodornase 29 Sodium bicarbonate. 31, 44 Streptomycin Sodium bromide. 65 Styramate.. 55 Sodium carboxymethyl cellulose- 32 Suavitil (benactyzine) 71 Sodium chloride. 44 Succinylcholine - 55 Sodium dehydrocholate. 32 Succiny lsulfathiazole - 2 Sodium dextrothyroxin 23 Sucostrin (succinylcholine) - 55 Sodium glutamate 47 Sulestrex (piperazine estrone sul- Sodium hypochlorite. 18 fate) - 41 Sodium indigotindisulfonate. 34 Sulfacetamide. Sodium iodide 41, 64 Sulfadiazine_. Sodium lactate_. 44 Sulfadimethoxine_ Sodium lauryl sulfate. 19 Sulfaethidole.. Sodium methicillin 2 Sulfa merazine-. Sodium morrhuate. 19 Sulfa methazine- Sodium p-amminobippurate. 34 Sulfa methizole Sodium perborate 18 Sulfa methoxazole.. Sodium phosphate 32 Sulfa methox ypyridazine Sodium psylliate. 19 Sulfa midine. Sodium radiochromate 34 Sulfa monomethoxine.. Sodium radio-iodide 35 Sulfamoxole. Sodlum ricinoleate_ 19 Sulfamyd (aulfacetamide) - Sodium salicylate_ 60 | Sulfaphenazole.. Sodium sulfate_ 32 Su Ifapyridine- Sodium tetradecyl sulfate - 19 Su lfasomizole - - Sodium thiosulfate 34 Su Ifasuxidine (succinylsulfathia- Bolaothyl (corticotropin) - 40 zole).. Bolganol (aurothioglucose). 10 Sulfathalidine (phthalylsulfathia- Soluthricin (tyrothricin). zole) _. Soma (carisoprodol) - 55 Sulfazole_. 1 Sombulex (hexobarbital) - 57 Sulfbromphthalein. 34 Sorbitol.. 21 Sulferrous (ferrous sulfate) - 28 Sotradecol (sodium tetracedy) Bulinpyrazone. 23, 60 sulfate). 19 Sulfisomidine_. Sparine (promazine) -- 70 Sulfsoxazole.. Spartase (potassium and magne- Sulfoxone - sium salts of aspartic aoid) 471 Sulfuno (sulfamoxole)- 94 ### Page 107 (OCR) Page 2 AC 91.11-1 7/19/63 4. AVAILABILITY. Although the contents of the guide should be interpreted and applied by physicians, who know the nature of airman activities, it 18 available to any purchaser. Order it from the Superintendent of Documents, U. S. Government Printing Office, Washington, D. C. 20401. The purchase price is 55 cents. 1th leighard T, M.D. Acting Civil Air Surgeon Par 4 ### Page 108 (OCR) file Copy On Shelf Federal spration ne AC NO: AC 91,11-1 **SLAVIATON ROS AIR TRAFFIC CONTROL** **AND GENERAL OPERATIONS** ADVISORY CIRCULAR ¡EFFECTIVE : 7/19/63 TO STATES OF PARE SUBJECT: GUIDE TO DRUG HAZARDS IN AVIATION 1. PURPOSE. This circular announces the publication and availability of the Guide to Drug Hazards in Aviation Medicine. 2. BACKGROUND. Section 91.11 of the Federal Aviation Regulations states: 91.11 Liquor and drugs. (a) No person may act as crewmember of a civil aircraft while - (1) Under the influence of intoxicating liquor; or (2) A means of determining the type of drug which "affects his faculties" has not, heretofore, been provided to airmen. The Guide to Drug Hazards in Aviation Medicine consists of a comprehensive list of all commonly-used prescription and nonprescription drugs, suitably indexed. The text of the guide groups those drugs with similar pharmacological effect. For each group a concise statement is made concerning: (1) the side effects, if any, which make them undesirable for use while serving as an airman, and (2) recommendations concerning the length of time an airman should wait after taking a drug before APPLICATION. A copy of the guide is in the possession of all FAA Aviation Medical Examiners. Examiners are prepared to provide advice and professional interpretation of guide recommendations as they might apply to specific circumstances involving the use of drugs by airmen. --- OpenAirDocs.org is an independent research project of [Contrail Labs](https://contraillabs.com/). It is not affiliated with the FAA or the NTSB. Source documents are U.S. government works in the public domain.