DEN83AA019

After taking off at aprx 2250, the acft was identified on radar & observed to climb on course to an alt of 10,700 ft. the acft then descended thru 10,500 ft & the crew reported they would maintain that alt. At about 2301 the acft was about 5 mi se of Colorado springs,CO & at 10,300 ft when radar contact was lost. The acft crashed in that area in a nearvertical descent. The outboard 8 ft of the right wing had separated in flight & impacted about 1/4 mi from the main wreckage. The right aileron had sheared in 3 pieces also, & was found near the failed wing. There was evidence that the the wing had yielded to a down & up loading (1 cycle) when it separated upward & rearward. All fracture surfaces had evidence of overload failures except the aileron control linkage which was further damaged on impact & could not be evaluated. Both plts were using medication that was contraindicated for use by airmen, & both plts had little sleep during the previous 48 hrs. Before the flt the plt seemed agitated & the coplt had an odor of beer.