As reported to the FAA. Reports are unverified, and codes are left as the FAA publishes them.
What was found
(CAN) AN OPERATOR EXPERIENCED AN IN-FLIGHT MAIN WHEEL SEPARATION ON TAKE-OFF. A REQUEST WAS MADE FOR EMERGENCY PERSONNEL AND EQUIPMENT TO BE ON STANDBY. AFTER A NORMAL EXTENSION OF THE LANDING GEAR VISUAL INSPECTION CONFIRMED THAT LT INNER MAIN WHEEL WAS MISSING. A/C MADE AN UNSCHEDULED LANDING. MAIN WHEEL BEARING FAILURE FOUND TO BE THE CAUSE. INVESTIGATION ON-GOING.