CHLORAMPHENICOL chloramphenicol (Chloromycetin) Undesirable effects in aviation: Early: nausea and vomiting, blurring of vision, loss of equilibrium.
Late: bone marrow damage, aplastic anemia.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Frequent medical examinations indicated for the next 2 weeks.
STREPTOMYCIN GROUP dihydrostreptomycin kanamycin (Kantrex) neomycin (Mycifradin) paromomycin (Humatin) streptomycin Undesirable effects in aviation: Oral administration: nausea, vomiting, cramping and loose stools; later, moniliasis (neomycin, paromomycin). Parenteral administration: severe auditory or vestibular damage (streptomycin, dihydrostreptomycin, neomycin, kanamycin); nephrotoxicity (neomycin, kanamycin); hepatotoxicity (paromomycin); fever, rash, allergic manifestations.
Use in aviation personnel: Airman duties contraindicated for 48 hours after use or in the presence of any later signs or symptoms. Frequent medical examinations indicated for the next 2 weeks. Medical condition would ordinarily preclude duty.
STREPTOMYCIN ALTERNATIVES cycloserine (Oxamycin) viomycin (Vinactane) Undesirable effects in aviation: Neurotoxicity, convulsions (cycloserine) ; renal and auditory toxicity (viomycin).
Use in aviation personnel: Same as for streptomycin.
SULFONES diaminodiphenylsulfone (Alvosulfon) glucosulfone (Promin) hydroxyethyl sulfone sodium acetosulfone (Promacetin) sulfoxone (Diasone) thiazolsulfone (Promizole) Undesirable effects in aviation: Excitement, dermatitis, hemolytic anemia.
Use in aviation personnel: Work contraindicated for 24 hours after use; no present application except in leprosy, which would ordinarily preclude work.
ANTITUBERCULOSIS SYNTHETICS amithiozone (Tibione) benzoylpas (Benzepas) ethionamide (Trecator) isoniazid (Cotinazin; Dinacrin; Ditubin; INH; Isolyn; Isonicop; Laniazid; Nydrazid; Rimifon; Tyvid) para-aminosalicylic acid (Pamisyl; Parapas; Parasal; Pasara) phenyl-p-aminosalicylate (Tebamin) pyrazinamide (Aldinamide) pyruvic acid isonicotinyl hydrazone thiocarbanidin (Thioban) Undesirable effects in aviation: Unpleasant taste and gastric irritation (aminosalicylates) ; drug fever, dermatitia, agranulocytosis (amithiozone); mild euphoria, vertigo, headache, dry mouth (isoniazid, ethionamide) ; hepatic damage, hyperuricemia (pyrazinamide).
Use in aviation personnel: Airman duties contraindicated for 48 hours after use; use limited to tuberculosis, which until arrested precludes work.
NITROFURAN DERIVATIVES furaltadone (Altafur) (withdrawn from market) furazolidone (Furoxone) nitrofurazone (Furacin) nitrofurantoin (Furadantin) Undesirable effects in aviation: Allergic sensitization (all derivatives) ; leucopenia, hemolytic anemia (nitrofurantoin, furaltadone) ; nausea, dizziness, pruritis, paralysis of lateral rectus of eye, diminished auditory acuity, peripheral neurological disturbances (furaltadone).
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Frequent medical examinations indicated for the next week.
URINARY ANTISEPTICS methenamine mandelate (Mandelamine) phenazopyridine (Pyridium) Undesirable effects in aviation: Relatively nontoxic; rare nausea.
Use in aviation personnel: Airman duties ordinarily not contraindicated after usual dosage.
POLYPEPTIDE ANTIBIOTICS bacitracin (Baciguent) colistin; sod. colistimethate (Coly-Mycin) polymyxin B (Aerosporin) tyrothricin (Bactratycin; Soluthricin) Undesirable effects in aviation: Topical use: relatively nonsensitizing. Systematic use: nephrotoxicity (bacitracin) ; neurotoxicity (polymyxin, colistin).
Use in aviation personnel: Airman duties not contraindicated after topical use; prohibited for 24 hours after systematic use, but medical condition would ordinarily preclude duty. Frequent medical examinations indicated for the next 2 weeks.
Undesirable effects in aviation: Nausea, vomiting, abdominal cramps, methemoglobinemia, hemolysis.
Use in aviation personnel: Airman duties contraindicated for 48 hours after use. Medical condition would ordinarily preclude duty.
EMETINE emetine Undesirable effects in aviation: Local irritation, cardiac depression and damage.
Use in aviation personnel: Airman duties contraindicated for 1 week after use. Medical condition would ordinarily preclude duty.
GLAUCARUBIN glaucarubin (Glarubin) Undesirable effects in aviation: Doses over 200 mg. daily may produce nausea and vomiting.
Use in aviation personnel: Work contraindicated for 24 hours after use. Frequent medical examinations indicated during the next week.
OXYQUINOLINE GROUP chiniofon (Yatren) diiodohydroxyquin (Diodoquin; Lanodoxin; Moebiquin; Quinadone; Yodoxin) iodochlorhydroxyquin (Enterokin; Enteroquinol; Nioform;
Quinambicide; Vioform) Undesirable effects in aviation: Local irritation; rare iodism.
Use in aviation personnel: Airman duties ordinarily not contraindicated during topical use; contraindicated for 2 days after systematic use. Disease requiring systematic use ordinarily precludes duty.
FUMAGILLIN fumagillin (Fugillin; Fumadil) Undesirable effects in aviation: Cramping, diarrhea, headache, vertigo, dermatitis, neutropenia.
Use in aviation personnel: Airman duties contraindicated for 1 week after use. Frequent medical examinations indicated for the next week.
METRONIDAZOLE metronidazole (Flagyl) Undesirable effects in aviation: Minor gastrointestinal symptoms and dizziness.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Frequent medical examinations are indicated for the next 2 weeks.
ARSENICALS arsphenamine (Salvarsan) carbarsone glycobiarsol (Milibis) neoarsphenamine oxophenarsine (Mapharsen) tryparsamide Undesirable effects in aviation: Local irritation, nitritoid reaction, Herxheimer reaction, jaundice, neuritis (arsphenamines) ;
optic atrophy (tryparsamide); largely obsolete.
Use in aviation personnel: Airman duties contraindicated during first week of therapy with carbarsone or glycobiarsol, and at all times during use of other drugs listed.
BISMUTH AND MERCURY COMPOUNDS bismuth subsalicylate and others mercuric salicylate and others Undesirable effects in aviation: May produce stomatitis, intestinal and renal epithelial damage.
Use in aviation personnel: Obsolete; use contraindicated.
GOLD COMPOUNDS aurothioglucose (Solganol) aurothioglycainide (Lauron) gold sodium thiomalate (Myochrysine) gold sodium thiosulfate (Auricidine; Aurolin) Undesirable effects in aviation: Metallic taste, stomatitis, pruritis, diarrhea, muscle pain, dermatitis, albuminuria, agranulocytosis.
Use in aviation personnel: Airman duties contraindicated for 48 hours after use or in presence of later symptoms; disease ordinarily precludes duty. Frequent medical examinations indicated for the next 2 weeks.
2. ANTIFUNGAL AGENTS
NYSTATIN nystatin (Mycostatin) Undesirable effects in aviation: Relatively nontoxic; occasional nausea, diarrhea, after oral administration, which may persist for several weeks.
Use in aviation personnel: Airman duties precludéd by presence of any side effects, but otherwise not contraindicated.
AMPHOTERICIN amphotericin B (Fungisone) Undesirable effects in aviation: Fever, chills, anorexia, nausea, vomiting, nephrotoxicity, cardiac depression.
Use in avlation personnel: Airman duties contraindicated for 48 hours after use. Frequent medical examinations indicated for the next 2 weeks. Medical condition requiring use would ordinarily be presumed to prevent duty.
GRISEOFULVIN griseofulvin (Fulvicin; Grifulvin) Undesirable effects in aviation: Relatively nontoxic; rare headache, insomnia, nausea, rash, fever, joint pains, leucopenia, psychomotor disturbances.
Use in aviation personnel: Airman duties contraindicated during first week of use, but not necessarily thereafter during continuation of therapy if toxicity clearly absent.
3. ANTIPROTOZOAL AGENTS
QUININE quinine Undesirable effects in aviation: Deafness, tinnitus, vertigo, nausea, cardiac depression, allergic hypersensitivity.
Use in aviation personnel: Airman duties contraindicated for 48 hours after use; may be permitted after that time if examination reveals no vestibular disturbances. However, medical condition would ordinarily preclude duty during therapeutic use.
CHLOROQUINE GROUP amodiaquin (Camoquin) chloroquine (Aralen) hydroxychloroquine (Plaquenil) quinacrine (Atabrine) Undesirable effects in aviation: Early: anorexia, nausea, diarrhea, headache, blurred vision, pruritis. Late: ocular palsies, neuropathies, lenticular opacities.
Use in aviation personnel: Airman duties not contraindicated during usual suppressive antimalarial doses; contraindicated for 48 hours after therapeutic dosage. Medical examination indicated before return to duty to eliminate presence of early or late toxic effects. Medical condition ordinarily precludes duty during therapeutic use.
CHLORGUANIDE GROUP chlorguanide (Guanatol; Paludrine) pyrimethamine (Daraprim) Undesirable effects in aviation: Toxicity relatively slight; nausea, vomiting, diarrhea (chlorguanide); dermatitis, marrow depression, convulsions (high doses of pyrimethamine).
Use in aviation personnel: Same as for chloroquine group.
PRIMAQUINE GROUP pamaquine (obsolete) pentaquine (obsolete) primaquine
6. ANTHELMINTICS
FLATWORM AGENTS aspidium (male fern) pelletierine quinacrine: see ANTIPROTOZOAL AGENTS Undesirable effects in aviation: Hendache, vertigo, blindness, collapse, convulsions.
Use in aulation personnel: Work contraindicated for 48 hours after use.
, CHLORINATED HYDROCARBONS carbon tetrachloride tetrachlorethylene Undesirable effects in aviation: Dizziness, staggering, narcosis;
later, hepatitis.
Use in aulation personnel: Work contraindicated for 48 hours after use. Frequent medical examinations indicated for the next 2 weeks.
PHENOL DERIVATIVES hexylresorcinol thymol Undesirable effects in avlation: Local irritation; but severe tox- . icity unlikely.
Use in aviation personnel: Airman duties contraindicated for 48 hours after use.
CYANINE DYES dithiazanine (Delvex) pyrvinium (Poquil; Povan; Vanquin) Undesirable effecta in aviation: Frequent nnusen, vomiting, and other gastrointestinal symptoms; possible nephrotoxicity.
Use in avlation personnel: Airman duties contraindicated for 2 days after use.
PIPERAZINES diethylcarbamazine (Hetrazan) piperazine (Antepar; Anthelcole; Oxucide; Pipazan) Undesirable effects in aviation: Infrequent nausea, vomiting, headaches, abdominal cramps, urticaria, neurological disturbances (piperazine); nausea, headache, fever, dermatitis, allergic reactions (diethylcarbamazine).
Use in aviation personnel: Airman duties contraindicated for 48 hours (piperazine), and 72 hours (diethylcarbamazine), after use.
BEPHENIOM bephenium (Alcopar) Undesirable effects in aviation: Slight nausea, vomiting, soft stools.
Use in aviation personnel: Airman duties contraindicated for 48 hours after use.
OTHER ANTHELMINTICS methylrosaniline (gentian violet) oil of chenopodium santonin Undesirable effects in aviation: Various mild and severe side effects.
Use in aviation personnel: Airman duties contraindicated for 2 days after use; obsolete.
4. METAL BINDING AGENTS (ANTIDOTES)
DIMERCAPROL dimercaprol (BAL) Undesirable effects in aviation: Massive symptoms may follow large therapeutic doses: unrest, weakness, fatigue, paresthesias, lacrimation, perspiration, vomiting, tachycardia.
Use in aviation personnel: Airman duties contraindicated for 1 week after use; metal poisoning for which dimercaprol was given would probably preclude work still further.
ETHYLENEDIAMINE TETRAACETIC ACID SALTS edathamil calcium-disodium (calcium disodium versenate) edathamil disodium (Endrate disodium) penthamil calcium trisodium Undesirable effects in aviation: Hypocalcemia (edathamil disodium), but all relatively nontoxic.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Disease requiring use of the agents would ordinarily preclude duty.
PENICILLAMINES acetylpenicillamine penicillamine Undesirable effects in aviation: Relatively nontoxic.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. Medical condition would be presumed to preclude duty.
5. AGENTS IN TROPICAL DISEASES
ANTIMONIALS antimony potassium tartrate (tartar emetic) stilbamine glucoside (Neostam) stibophen (Fuadin) Undesirable effects in aviation: Trivalent forms (tartar emetic, stibophen) may produce coughing, vomiting, pneumonitis, arthralgic, bradycardia, thrombocytopenia. Pentavalent forms may produce vomiting, anaphylactoid reactions, hepatitis.
Use in aviation personnel: Airman duties contraindicated for 72 hours after use. Frequent medical examinations indicated for the next 2 weeks. Medical condition would ordinarily preclude duty.
SYNTHETICS aminostilbamidine antrycide hydroxystilbamidine lucanthone (Miracil D) metamidium stilbamidine suramin (Bayer 205; Germanin; Naphuride) Undesirable effects in aviation: Various mild and severe adverse effects.
Use in aviation personnel: Airman duties contraindicated for 1 week after use, but patients requiring these agents must be considered unfit for duty.
7. ANTICANCER AGENTS
ALKYLATING AGENTS busulfan (Myleran) chlorambucil (Leukeran) cyclophosphamide (Cytoxan) epipropidine (Lponate) mechlorethamine (Mustargen; nitrogen mustard) sarcolysin thiotepa triethylenemelamine (TEM) uracil mustard Undesirable effects in aviation: Certain members (nitrogen mustards) are local vesicants and necrotizing agents; all may produce abdominal pain, diarrhea, nausea, muscular paralysis, convulsions, damage to the bone marrow (early and delayed).
Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in the presence of any of the adverse effects.
Medical conditions requiring such medications would ordinarily preclude flying.
FOLIC ACID ANTAGONISTS aminopterin methotrexate (amethopterin) Undesirable effects in aviation: Ulceration of buccal mucosa, bleeding gums, diarrhen, purpura, ecchymoses.
Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in the presence of any adverse effects. Medical condition would ordinarily preclude duty.
PURINE AND PYRIMIDINE ANTAGONISTS 5-fluorouracil mercaptopurine (Purinethol) Undesirable effects in aviation: Nausea, vomiting, bone marrow depression with bleeding, thrombopenin, leucopenia.
Use in avlation personnel: Airman duties contraindicated for 1 week after use, or in the presence of adverse effects. Medical condition would ordinarily preclude duty.