OTHERS azaserine demecolcine (Colcemid) meractinomycin (Actinomycin D) puromycin urethane vinblastine (Velban) Undesirable effects in aviation: Nausea, vomiting, diarrhea and various other symptoms.
Use in aviation personnel: Airman duties contraindicated for 1 week after use; also, on medical grounds, patient must be presumed unfit for duty.
cetyl pyridinium (Ceepryn) soap sodium lauryl sulfate sodium tetradecyl sulfate (Sotradecol; Tergitol) triclobisonium (Triburon) Undesirable effects in aviation: Relatively nontoxic.
Use in aviation personnel: Airman duties not restricted after topical use in conventional dosage.
SCLEROSING AGENTS sodium morrhuate sodium psylliate sodium ricinoleate sodium tetracedyl sulfate (Sotradecol) Undesirable effects in aviation: Local irritation and inflammation.
Use in aviation personnel: Airman duties contraindicated for 1 week after use; thereafter permitted when examination shows vascular process healed.
PROTECTIVES, EMOLLIENTS, COSMETICS Undesirable effects in aviation: None.
Use in aviation personnel: Airman duties not contraindicated.
SUN TAN AND DEPIGMENTING PREPARATIONS dioxyacetone (Man-Tan) methoxsalen (Meloxine; Methoxa-Dome; Oxsoralen) monobenzone (Benoquin) Undesirable effects in aviation: May produce severe erythema and blistering; liver damage from systemic administration of methoxsalen.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use or in presence of signs of toxicity. Frequent medical examinations indicated for the next 2 weeks.
9. CARDIOVASCULAR AGENTS
CARDIAC GLYCOSIDES acetyldigitoxin (Acylanid) deslanoside (Cedilanid D) digilanid digitalis digitoxin digoxin (Lanoxin) gitalin (Gitalgin) ouabain Undesirable effects in aviation: May produce anorexia, nausea, vomiting, diarrhea, visual abnormalities, arrhythmias.
Use in aviation personnel: Airman duties contraindicated for 2 weeks after initiation of use. Thereafter, well stabilized digitalization is not of itself a contraindication to duty. However, the medical condition requiring digitalization would almost certainly preclude work.
ANTIARRHYTHMICS quinidine procaine amide (Pronestyl) Undesirable effects in aviation: Nausea, vomiting, diarrhea, tinnitus, arrhythmias, sensitivity phenomena, thrombocytopenia from quinidine; hypotension, granulocytopenia from procaine amide.
Use in aulation personnel: Airman duties contraindicated for 2 days after cessation of treatment; patient ordinarily considered permanently unfit for work because of underlying disease.
AGENTS IN HEART BLOCK ephedrine isoproterenol (Aleudrin; Asdrin; Isopro; Ieuprel) Undesirable effects in aviation: Palpitation, tachycardia, nervousness.
Use in aulation personnel; Airman duties contraindicated for 6 hourg after use; however, medical condition (heart block) must be presumed to prohibit duty permanently.
DIURETICS, OSMOTIC AND ACIDIFYING ammonium chloride potassium salts sorbitol area Undesirable effecta in aviation: Dehydration, electrolyte disturbances.
Use in aviation personnel: Airman duties contraindicated for 24 hours or longer after use, and in any case are permissible only after examination shows effecte of agenta on electrolytes to have ceased. Medical condition ordinarily precludes duty.
DIURETICS, XANTHINES aminophylline (Aminocardol; Cardophyllin; Diophyllin; Metaphyllin) theophylline Undesirable effects in aviation: Immediate nausea and vomiting after oral, rectal or intravenous administration; later dehydration, electrolyte disturbances.
Use in avlation personnel: Airman duties contraindicated for 24 hours or longer after use, and in any case are permissible only after examination shows effects of agente on electrolytes to have ceased. Medical condition ordinarily precludes duty.
DIURETICS, MERCURIALS chlormerodrin (Neohydrin) meralluride (Mercuhydrin) mercaptomerin (Thiomerin) mercumatilin (Cumertilin) mercurophylline (Mercuzanthin) mersalyl sodium and theophylline (Diureal; Merphylline; Salyrgan theophylline) Undesirable effects in aviation: Stomatitis, renal damage, fever, rash; ventricular fibrillation after intravenus use; electrolyte abnormality.
Use in aulation personnel: Airman duties contraindicated for 48 hours after use; or 1 week after appearance of any adverse effects, and in any case are permissible only after examination shows effects of agents on electrolytes to have ceased. Medical condition ordinarily precludes duty.
DIURETICS, CARBONIC ANHYDRASE INHIBITORS acetazolamide (Diamox) dichlorphenamide (Daranide) ethoxzolamide (Cardrase) methazolamide (Neptazane) Undesirable effects in aviation: Anorexia, fatigue, drowsiness, tingling, leg pains.
Use in aviation personnel: Airman duties contraindicated for 48 hours after use of agents for any reason, or for 1 week after appearance of any adverse effects. However, usual indications ordinarily (edema), or absolutely (epilepsy, glaucoma) contraindicate duty.
DIURETICS, THIAZIDE AND RELATED bendroflumethinzide (Naturetin) benzthiazide (Di-ademil) chlorthalidone (Hygroton) chlorthiazide (Diuril) flumethiazide (Ademol) hydrochlorothiazide (Esidrix; Hydrodiuril; Oretic) methy clothiazide (Enduron) polythiazide (Renese) trichlormethiazide (Naqua) Undesirable effects in aviation: Minor nausea and vomiting;
weakness from potassium deficiency; rare agranulocytosis, thrombocytopenia.
Use in avlation personnel: Airman duties contraindicated for 48 hours after use, or for 1 week after appearance of any adverse effects. Medical condition requiring use would ordinarily preclude duty permanently.
DIURETICS, AMINOURACIL DERIVATIVES aminometradine (Mictine) amisometradine (Rolicton) Undesirable effects in aviation: Toxicity minimal but nausea, vomiting, diarrhea, dizziness and rash may appear.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use (nearly obsolete).
DIURETICS, ALDOSTERONE ANTAGONISTS spironolactone (Aldactone) 22
Undesirable effects in aviation: Rare headache, drowsiness, abdominal pain.
Use in avlation personnel: Airman duties contraindicated for 24 hours after use. Medical conditions requiring use would ordinarily preclude duty permanently.
DIURETICS, CATIONIC EXCHANGE RESINS carbacrylamine resins (Carbo-Resin) Undesirable effects in aviation: May produce nausea from local irritation; constipation from bulk.
Use in aviation personnel: Airman duties contraindicated in the presence of any side effects. Howevet, conditions requiring use would ordinarily preclude duty permanently. (Little used).
AGENTS INHIBITING RENAL TUBULES (REABSORPTION OF URIC ACID; EXCRETION OF PENICILLIN) probenecid (Benemid) sulfinpyrazone (Anturane) zoxazolamine (Flexin) (withdrawn from market) Undesirable effects in aviation: Nausea, vomiting, anorexia, rashes; activation of peptic ulcer and bone marrow depression (sulfinpyrazone) ; liver damage (zoxazolamine).
Use in aviation personnel: Airman duties contraindicated for 48 hours after use. Frequent medical examinations for the next week.
AGENTS IN ATHEROSCLEROSIS heparin nicotinic acid; niacin saflower oil (Saff; Saffola; Saffolin) sitosterols (Cytellin) sodium dextrothyroxin (Choloxin) thyrotropic acid (Triopron) triparanol (MER-29) (withdrawn from market) unsaturated fatty acids Undesirable effects in aviation: Minimal adverse effects except for unpleasant immediate flushing from nicotinic acid and undetermined hazards (alopecia, cataracts, accumulation of cholesterol precursor) from triparanol.
Use in aviation personnel: Airman duties contraindicated during use of triparanol, for 4 hours after nicotinic acid, 6 hours after heparin; otherwise not contraindicated if adverse effects absent.
However, the presence of atherosclerosis requiring treatment ordinarily precludes duty.
HYPOTENSIVES, CENTRAL alkavervir (Veriloid) hydralazine (Apresoline) protoveratrines A & B (Veralba) rauwolfia group reserpine (Crystoserpine; Eskaserp; Rau-Sed; Reserpoid; Roxinoid; Serfin; Serpasil; Serpiloid) syrosingopine (Singoserp) Undesirable effects in aviation: Postural hypotension, headache, vomiting, diarrhea. From hydralazine: edema, urticaria, polyneuritis, systemic lupus erythematosus. From rauwolfia, reserpine, syrosingopine: sedation, nightmares, parkinsonism, nasal stuffiness, bleeding from peptic ulcer.
Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in presence of any later drug symptoms.
Hypertension requiring treatment ordinarily contraindicates duty. However, patients with formerly mild hypertension, who have been completely controlled by the lower conventional doses of drugs for periods of 6 months or longer, and who show no postural hypotension or other adverse effects of drug therapy, may be considered for restricted duty.
HYPOTENSIVES, GANGLION BLOCKERS chlorisondamine (Ecolid) hexamethonium (Bistrium; Esomid; Hexameton; Hiohex; Methjum) mecamylamine (Inversine) pempidine (Perolysen) pentolinium (Ansolysen) tetraethylammonium (Etamon) trimethaphan (Arfonad) Undesirable effects in aviation: Postural hypotension, impaired cerebral and renal circulation, dilated pupils, dry mouth, urinary retention, constipation; central stimulation (mecamylamine).
Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in presence of any later drug symptoms.
Hypertension requiring treatment ordinarily contraindicates duty. However, patients with formerly mild hypertension, who have been completely controlled by the lower conventional 24
doses of drugs for periods of 6 months or longer, and who show no postural hypotension or other adverse effects of drug therapy, may be considered for restricted duty.
HYPOTENSIVES, SYMPATHOLYTICS bretylium (Darenthin) guanethidine (Ismelin) methyldopa (Aldomet) Undesirable effects in aviation: Postural hypotension, nasal stuffiness, drooping eyelids, bradycardia, diarrhea, muscular weakness, mental confusion or sedation, facial pain (bretylium).
Use in aviation personnel: Airman duties contraindicated for 1 week after use, or in presence of any later drug symptoms.
Hypertension requiring treatment ordinarily contraindicates duty. However, patients with formerly mild hypertension, who have been completely controlled by the lower conventional doses of drugs for periods of 6 months or longer, and who show no postural hypotension or other adverse effects of drug therapy, may be considered for restricted duty.
10. SMOOTH MUSCLE AGENTS
NITRITES AND NITRATES amyl nitrite erythrityl tetranitrate (Erythrol tetranitrate) glyceryl trinitrate isorbide dinitrate (Isordil) mannitol hexanitrate (Maxitrate) octyl nitrite (Octrite) pentaerythritol tetranitrate (Angitet; Circulin; Duotrate; Pencard; Pentritol; Peritrate; Rythritol; Vasodilatol) trolnitrate (Metamine) Undesirable effects in aviation: Flushing, throbbing headache, palpitation, fainting.
Use in aviation personnel: Airman duties contraindicated for 12 hours after use. It is to be noted that certain indications (angina pectoris) are absolutely incompatible with duty, while others (mild hypertension, completely controlled for 6 months and without adverse drug effects) might not be disqualifying for certain ground duties.
XANTHINES aminophylline diphylline oxytriphylline (Choledyl) theophylline methyl glucamine (Glucophylline) theophylline sodium glycinate (Theoglycinate) Undesirable effects in aviation: Gastric irritation after oral use vomiting after intravenous (see also DIURETICS and PSYCHIC STIMULANTS for other uses).
Use in aviation personnel: Airman duties contraindicated for 24 hours after use.
PAPAVERINE AND SIMILAR AGENTS amotriphene (Myodil) cyclandelate (Cyclospasmol) dioxyline (Paveril) 26
ethyl papaverine (Ethaverine) papaverine Undesirable effects in aviation: Cardiac depreasion possible from papaverine.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. However, underlying medical conditions (angina pectoris or phlebothrombosis) would contraindicate duty.
ERGOT ALKALOIDS dihydroergotamine (DHE 45) ergotamine (Gynergan) methyl ergonovine (Methergine) Undesirable effects in aviation: Nausea, vomiting, vascular spasm.
Use in avlation personnel: Airman duties contraindicated for 24 hours after use, or if any side effects are present. It should be noted that repeated attacks of migraine are disqualifying for duty.
POSTERIOR PITUITARY PREPARATIONS oxytocin (Pitocin; Syntocinon) posterior pituitary vasopressin (Pitressin) Undesirable effects in aviation: Nausea, abdominal cramps cerebral or coronary artery spasm, water intoxication.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. However, most conditions requiring use (labor, intestinal paresis) ordinarily contraindicate duty for a much longer period; completely controlled diabetes insipidus might be judged compatible with certain duties.
11. AGENTS IN BLOOD DISEASES
IRON PREPARATIONS dextriferon (Astrafer) ferric ammonium citrate ferrocholinate (Chel-Iron; Ferrolip) ferrous fumarate (Ferrospan; Fumasorb; Hemorate; Ircon; Toleron) ferrous gluconate (Fergon; Irox; Nionate) ferrous sulfate (Feosol; Ferralyn; Ferro-Theron; Irosul; Sulferrous) iron dextran complex (Imferon) iron oxide, saccharated (Proferrin) polyferose (Tefron) Undesirable effects in aviation: Indigestion from oral adminis.
tration; nitritoid reactions, hemochromatosis from intravenous.
Use in aulation personnel: Airman duties not contraindicated after oral use; contraindicated for 12 hours after intravenous use.
VITAMIN B,,, LIVER, FOLIC ACID PREPARATIONS calcium leucovorin cyanocobalamin (Vitamin B1a) folic acid hydroxocobalamin (alpha-Redisol) liver injection Undesirable effects in aviation: None.
Use in ablation personnel: Airman duties not contraindicated by иве.
HEPARIN PREPARATIONS heparin potassium, sublingual (Clarin) heparin repository (Depo-Heparin) heparin sodium (Hed-Heparin; Lipo-Hepin; Liquaemin) Undesirable effects in aviation: Nontorio except for danger of bleeding from excessive doses.
Use in aviation personnel: Airman duties contraindicated for 24 hours after use. However, medical status ordinarily precludes duty.
HEPARIN ANTAGONISTS hesadimethrine (Polybrene) protamine tolonium (Blutene) Undesirable effects in aviation: Protamine may give shock from overdosage.
Use in aulation personnel: Airman duties contraindicated for 24 hours after use; however, the medical indication would ordinarily prohibit duty.
COUMARIN AND INDANDIONE DERIVATIVES acenocoumarin (Sintrom) anisindone (Miradon) bishydroxycoumarin (Dicumarol) cyclocumarol (Cumpyran) diphenadione (Dipaxin) ethylbiscoumacetate (Tromexan) phenindione (Danilone; Hedulin; Indon) phenprocoumon (Liquamar) warfarin (Coumadin; Panwarfin; Prothromadin) Undesirable effects in aviation: Danger of bleeding; vomiting, diarrhea, urticaria; hepatitis and agranulocytosis (indandiones).
Use in aviation personnel: Airman duties contraindicated during first month of therapy; thereafter therapy per se may not be contraindicated if administration well controlled and signs of overdosage absent. However, the most common use, underlying coronary artery disease, contraindicates duty on medical grounds.
PROTEOLYTIC AND OTHER ENZYMES chymotrypsin (Chymar; Chymotest; Enzeon) fibrinolysin (human) (Actase; Thrombolysin) pancreatic dornase (Dornavac) streptokinase-streptodornase (Varidase) trypsin (Orenzyme; Parenzyme; Tryptar; Tryptest) Undesirable effects in aviation: Febrile reactions, allergic symptoms after parenteral use.